STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tgttRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (373 aa)    
Predicted Functional Partners:
queA
S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
 0.994
Tlie_0637
Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
     
 0.842
Tlie_0630
Ribonuclease, Rne/Rng family; PFAM: Ribonuclease E/G family; S1 RNA binding domain; TIGRFAM: ribonuclease, Rne/Rng family; COGs: COG1530 Ribonuclease G and E; InterPro IPR018247: IPR003029: IPR019307: IPR004659; KEGG: aco:Amico_0611 ribonuclease, Rne/Rng family; PFAM: RNA-binding protein AU-1/Ribonuclease E/G; RNA binding S1 domain protein; SPTR: Ribonuclease, Rne/Rng family; TIGRFAM: ribonuclease, Rne/Rng family.
     
 0.830
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
    0.829
Tlie_0635
Hydrolase, TatD family; PFAM: TatD related DNase; TIGRFAM: hydrolase, TatD family; COGs: COG0084 Mg-dependent DNase; InterPro IPR012278: IPR018228: IPR001130: IPR015991; KEGG: aco:Amico_0616 hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease; SPTR: Hydrolase, TatD family; TIGRFAM: hydrolase, TatD family.
  
    0.827
smc
Condensin subunit Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family.
  
    0.810
Tlie_0628
PFAM: Radical SAM superfamily; TIGRFAM: radical SAM family uncharacterized protein; COGs: COG1032 Fe-S oxidoreductase; InterPro IPR007197: IPR006638; KEGG: aco:Amico_0609 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
       0.806
Tlie_0629
Protein of unknown function DUF2344; PFAM: Uncharacterized protein conserved in bacteria (DUF2344); TIGRFAM: radical SAM-linked protein; COGs: COG5011 conserved hypothetical protein; InterPro IPR018768; KEGG: aco:Amico_0610 hypothetical protein; PFAM: Protein of unknown function DUF2344; SPTR: Putative uncharacterized protein.
       0.806
Tlie_0632
RNA methylase; PFAM: Methyltransferase small domain; COGs: COG4123 O-methyltransferase; InterPro IPR002052: IPR000241; KEGG: aco:Amico_0613 methyltransferase small; PFAM: RNA methylase; SPTR: Putative N-6 adenine-specific DNA methylase.
       0.806
rsmI
Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
     
 0.806
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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