STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlie_0706PFAM: DEAD/DEAH box helicase; COGs: COG1199 Rad3-related DNA helicase; InterProIPR014013: IPR001650: IPR011545: IPR014001: IPR 006554: IPR006555; KEGG: aco:Amico_0691 helicase C2; PFAM: DEAD/DEAH box helicase domain protein; SMART: helicase c2; DEAD-like helicase; Helicase-like, DEXD box c2 type; SPTR: Helicase c2. (638 aa)    
Predicted Functional Partners:
Tlie_1197
DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; DNA polymerase family A; 5'-3' exonuclease, N-terminal resolvase-like domain; TIGRFAM: DNA polymerase I; COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR019760: IPR002421: IPR008918: IPR001098: IPR 002298: IPR018320: IPR020046: IPR020047; KEGG: aco:Amico_1259 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain [...]
   
 0.984
sbcD
Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.979
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.978
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.978
Tlie_1123
RNA polymerase Rpb6; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 0.976
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.917
Tlie_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.904
Tlie_1782
DNA-directed DNA polymerase; PFAM: Phosphoribosyl transferase domain; impB/mucB/samB family C-terminal; impB/mucB/samB family; IMS family HHH motif; COGs: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; InterPro IPR017963: IPR001126; KEGG: lpn:lpg1703 SOS mutagenesis and repair UmuC protein; PFAM: UMUC domain protein DNA-repair protein; PRIAM: DNA-directed DNA polymerase; SPTR: DNA-directed DNA polymerase; Belongs to the DNA polymerase type-Y family.
  
 
 0.900
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.895
Tlie_1082
KEGG: aco:Amico_1052 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein.
  
 0.895
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
Server load: high (82%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.