STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlie_0796AAA ATPase central domain protein; PFAM: ATPase family associated with various cellular activities (AAA); InterProIPR019734: IPR013026: IPR003959: IPR001440: IPR 000641: IPR003593; KEGG: nth:Nther_1502 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; Tetratricopeptide TPR_1 repeat-containing protein; SMART: AAA ATPase; Tetratricopeptide repeat; SPTR: AAA ATPase central domain protein. (885 aa)    
Predicted Functional Partners:
ruvA
Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
 
 0.973
ruvC
Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
  
 
 0.824
queA
S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
  
  
 0.790
Tlie_0093
MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: tai:Taci_0862 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase CheR-type; PRIAM: Protein-glutamate O-methyltransferase; SMART: MCP methyltransferase CheR-type; SPTR: MCP methyltransferase, CheR-type.
   
   0.782
fliE
PFAM: Flagellar hook-basal body complex protein FliE; TIGRFAM: flagellar hook-basal body complex protein FliE; InterPro IPR001624; KEGG: tnp:Tnap_1437 flagellar hook-basal body complex subunit FliE; PFAM: flagellar hook-basal body complex protein FliE; SPTR: Flagellar hook-basal body complex protein FliE; TIGRFAM: flagellar hook-basal body complex subunit FliE.
    
 
 0.761
Tlie_1369
PFAM: Peptidase family M23; COGs: COG4942 Membrane-bound metallopeptidase; InterPro IPR016047; KEGG: tai:Taci_0489 peptidase M23; PFAM: Peptidase M23; SPTR: Peptidase M23.
   
 
 0.757
Tlie_1197
DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; DNA polymerase family A; 5'-3' exonuclease, N-terminal resolvase-like domain; TIGRFAM: DNA polymerase I; COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR019760: IPR002421: IPR008918: IPR001098: IPR 002298: IPR018320: IPR020046: IPR020047; KEGG: aco:Amico_1259 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain [...]
  
  
 0.709
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.704
Tlie_0795
PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR016473: IPR016192: IPR002125; KEGG: aco:Amico_0406 CMP/dCMP deaminase zinc-binding protein; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: ComE operon protein 2.
       0.686
Tlie_0797
Metal dependent phosphohydrolase; PFAM: HD domain; TIGRFAM: uncharacterized domain HDIG; COGs: COG2316 hydrolase (HD superfamily); InterPro IPR006674: IPR006675; KEGG: aco:Amico_0407 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SPTR: Metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase.
       0.660
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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