STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlie_0801Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792: IPR001789; KEGG: aco:Amico_0408 two component transcriptional regulator, LuxR family; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family. (210 aa)    
Predicted Functional Partners:
Tlie_0802
PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR018486: IPR011712: IPR003594; KEGG: aco:Amico_0409 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; SPTR: Putative sensory box sensor histidine kinase.
 
 0.980
Tlie_1463
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR004358: IPR003594: IPR005467; KEGG: gem:GM21_1102 PAS/PAC sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: PAS/PAC sensor signal transduction histidine kinase.
 
 
 0.897
Tlie_0494
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase; HAMP domain; Cache domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG4585 Signal transduction histidine kinase; InterProIPR004010: IPR003660: IPR011712: IPR003594: IPR 005467; KEGG: bbe:BBR47_16050 probable methyl-accepting chemotaxis protein; PFAM: ATP-binding region ATPase domain protein; Cache domain protein; histidine kinase HAMP region domain protein; histidine kinase dimerisation and phosphoacceptor region; SMART: histidine kinase HAMP region domain protein; ATP-binding region ATPas [...]
 
 
 0.896
Tlie_1854
PFAM: GGDEF domain; Response regulator receiver domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789: IPR000014: IPR000160: IPR013767; KEGG: tit:Thit_0615 response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor; PFAM: GGDEF domain containing protein; response regulator receiver; PAS fold domain protein; SMART: GGDEF domain containing protein; response regulator receiver; PAS domain containing protein; SPTR: Response regulator r [...]
  
 
 0.629
Tlie_0800
PFAM: Peptidase family S58; COGs: COG3191 L-aminopeptidase/D-esterase; InterPro IPR005321; KEGG: tte:TTE1796 L-aminopeptidase/D-esterase; PFAM: peptidase S58 DmpA; SPTR: L-aminopeptidase/D-esterase.
       0.590
Tlie_0055
Diguanylate cyclase with PAS/PAC and GAF sensors; PFAM: GAF domain; GGDEF domain; PAS fold; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterProIPR003018: IPR000160: IPR000014: IPR013656: IPR 000700; KEGG: aco:Amico_1621 diguanylate cyclase with GAF sensor; PFAM: GGDEF domain containing protein; GAF domain protein; PAS fold-4 domain protein; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase with GAF sensor; TIGRFAM: diguanylate cyclase; PAS sensor protein.
  
 
 0.538
Tlie_1620
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR005467: IPR003594: IPR004358; KEGG: tai:Taci_0545 histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensory transduction histidine kinase.
  
 
 0.529
Tlie_0799
KEGG: dhd:Dhaf_3079 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.426
Tlie_1276
Metal dependent phosphohydrolase; PFAM: HD domain; COGs: COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain; InterPro IPR003018: IPR006674: IPR003607; KEGG: tai:Taci_0059 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; GAF domain protein; SMART: metal-dependent phosphohydrolase HD region; SPTR: Metal dependent phosphohydrolase.
  
 
 0.425
Tlie_0036
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789: IPR001867; KEGG: aco:Amico_1683 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family.
  
 
 0.413
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.