STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysSPFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR001943: IPR015803: IPR015273: IPR002308; KEGG: aco:Amico_1002 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: Cysteine--tRNA ligase; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (476 aa)    
Predicted Functional Partners:
Tlie_0368
TIGRFAM: serine O-acetyltransferase; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451: IPR005881; KEGG: dtu:Dtur_1260 serine O-acetyltransferase; SPTR: Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase.
 
  
 0.986
Tlie_1671
Pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme; COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR005479; KEGG: cdl:CDR20291_1562 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase A.
  
 
 0.917
Tlie_0367
Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR005856: IPR005859: IPR000634; KEGG: aco:Amico_0096 cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase A; TIGRFAM: cysteine synthase; cysteine synthase A.
  
 
 0.909
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
 
 
 0.853
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 
  
 0.807
Tlie_0945
RNA methyltransferase, TrmH family, group 3; PFAM: SpoU rRNA Methylase family; RNA 2'-O ribose methyltransferase substrate binding; TIGRFAM: rRNA methylase, putative, group 3; COGs: COG0566 rRNA methylase; InterPro IPR004441: IPR013123: IPR001537; KEGG: aco:Amico_0782 RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; SPTR: RNA methyltransferase, TrmH family, group 3; TIGRFAM: RNA methyltransferase, TrmH family, group 3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA met [...]
 
 
 0.779
Tlie_0899
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
    0.728
leuS
PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR001412: IPR002300: IPR013155: IPR002302; KEGG: tai:Taci_0698 leucyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ia; tRNA synthetase valyl/leucyl anticodon-binding; SPTR: Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase.
 
 
 0.721
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
    0.704
Tlie_0896
Xanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; COGs: COG0503 Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; InterPro IPR000836; KEGG: aco:Amico_0245 xanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Xanthine phosphoribosyltransferase; SPTR: Xanthine phosphoribosyltransferase.
       0.697
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.