STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tlie_1007DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. (556 aa)    
Predicted Functional Partners:
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
   
 0.856
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.766
dxs
1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
  
  
 0.684
Tlie_1009
PFAM: S4 domain; FtsJ-like methyltransferase; TIGRFAM: hemolysin TlyA family protein; COGs: COG1189 rRNA methylase; InterPro IPR002942: IPR004538: IPR002877; KEGG: aco:Amico_0849 hemolysin A; PFAM: RNA-binding S4 domain protein; ribosomal RNA methyltransferase RrmJ/FtsJ; SMART: RNA-binding S4 domain protein; SPTR: Hemolysin A; TIGRFAM: hemolysin A.
  
  
 0.679
xseB
Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.
     
 0.667
Tlie_1011
PFAM: Polyprenyl synthetase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: aco:Amico_0851 geranyltranstransferase; PFAM: Polyprenyl synthetase; SPTR: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
     
 0.642
mfd
DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
 
   
 0.628
ruvA
Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
  
 0.621
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.616
Tlie_1782
DNA-directed DNA polymerase; PFAM: Phosphoribosyl transferase domain; impB/mucB/samB family C-terminal; impB/mucB/samB family; IMS family HHH motif; COGs: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; InterPro IPR017963: IPR001126; KEGG: lpn:lpg1703 SOS mutagenesis and repair UmuC protein; PFAM: UMUC domain protein DNA-repair protein; PRIAM: DNA-directed DNA polymerase; SPTR: DNA-directed DNA polymerase; Belongs to the DNA polymerase type-Y family.
  
  
 0.578
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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