STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Tlie_1615NAD(P)-dependent nickel-iron dehydrogenase catalytic subunit; PFAM: Nickel-dependent hydrogenase; COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501: IPR018194; KEGG: aco:Amico_1553 nickel-dependent hydrogenase large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: Nickel-dependent hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (475 aa)    
Predicted Functional Partners:
Tlie_1616
Hydrogen dehydrogenase; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; COGs: COG1941 Coenzyme F420-reducing hydrogenase gamma subunit; InterPro IPR006137; KEGG: aco:Amico_1554 NADH ubiquinone oxidoreductase 20 kDa subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; PRIAM: Hydrogen dehydrogenase; SPTR: Hydrogen dehydrogenase.
 
 
 0.996
Tlie_1617
NADH:ubiquinone oxidoreductase, subunit G, iron-sulfur binding protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Molybdopterin oxidoreductase; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Molybdopterin oxidoreductase Fe4S4 domain; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR001041: IPR017896: IPR019574: IPR006963: IPR 006656: IPR017900: IPR006655; KEGG: aco:Amico_1555 NADH:ubiquinone oxidoreductase, subunit G, iron-sulfur binding protein; PFAM: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; molybdopterin oxidor [...]
 
 
 
 0.971
Tlie_1618
NADH dehydrogenase (quinone); PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; 4Fe-4S binding domain; Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterProIPR017896: IPR009737: IPR011538: IPR019554: IPR 019575: IPR017900: IPR001949; KEGG: aco:Amico_1556 NADH dehydrogenase (quinone); PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Sucraseferredoxin family protein; Soluble ligand binding domain; NADH ubiquin [...]
   
 
 0.966
Tlie_1621
PFAM: Respiratory-chain NADH dehydrogenase 24 Kd subunit; TIGRFAM: NADH-quinone oxidoreductase, E subunit; COGs: COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit; InterPro IPR002023; KEGG: aco:Amico_1558 NADH dehydrogenase (ubiquinone) 24 kDa subunit; PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; SPTR: NADH dehydrogenase I, E subunit.
   
 
 0.955
Tlie_1614
TIGRFAM: hydrogenase maturation protease; COGs: COG0680 Ni Fe-hydrogenase maturation factor; InterPro IPR000671; KEGG: aco:Amico_1552 Ni,Fe-hydrogenase maturation factor; SPTR: Ni,Fe-hydrogenase maturation factor; TIGRFAM: hydrogenase maturation protease.
 
  
 0.953
Tlie_1465
Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterProIPR013027: IPR000103: IPR001949: IPR011538: IPR 019554: IPR019575; KEGG: dal:Dalk_2559 respiratory-chain NADH dehydrogenase domain 51 kDa subunit; PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Solub [...]
   
 
 0.899
Tlie_1248
Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; 4Fe-4S binding domain; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterProIPR017900: IPR011538: IPR019554: IPR019575: IPR 017896; KEGG: tko:TK1613 NADH:ubiquinone oxidoreductase, NADH-binding subunit F; PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; SPT [...]
  
 
 0.889
Tlie_1619
NAD(P)-dependent iron-only hydrogenase iron-sulfur protein; KEGG: aco:Amico_1557 NADP-reducing hydrogenase, subunit B; SPTR: NADP-reducing hydrogenase, subunit B.
   
   0.807
Tlie_1464
NADH:ubiquinone oxidoreductase, subunit G, iron-sulfur binding protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Molybdopterin oxidoreductase; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Molybdopterin oxidoreductase Fe4S4 domain; COGs: COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G); InterProIPR017900: IPR001041: IPR019574: IPR006963: IPR 006656: IPR017896; KEGG: dtu:Dtur_0076 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; PFAM: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; molybdopterin [...]
 
 
 
 0.759
Tlie_1249
PFAM: Pyridine nucleotide-disulphide oxidoreductase; Molybdopterin oxidoreductase; 4Fe-4S binding domain; Molybdopterin oxidoreductase Fe4S4 domain; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR000759: IPR017900: IPR006126: IPR001041: IPR 013027: IPR006963: IPR006656: IPR017896; KEGG: slo:Shew_0809 formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; ferredoxin; molybdopterin oxidoreductase Fe4S4 region; SPTR: Molybdopterin oxidoreductase.
   
 
 0.758
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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