Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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Score
Tlie_1663Phospholipase D/Transphosphatidylase; COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; InterPro IPR001736; KEGG: mes:Meso_3886 cardiolipin synthetase 2; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; SPTR: Phospholipase D/Transphosphatidylase. (480 aa)    
Predicted Functional Partners:
Tlie_0850
PFAM: Phosphatidylglycerophosphatase A; COGs: COG1267 Phosphatidylglycerophosphatase A and related protein; InterPro IPR007686; KEGG: aco:Amico_0391 phosphatidylglycerophosphatase A; PFAM: phosphatidylglycerophosphatase A; SPTR: Phosphatidylglycerophosphatase A.
     
 0.911
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.760
Tlie_1662
PFAM: Peptidase family M20/M25/M40; COGs: COG4187 Arginine degradation protein (predicted deacylase); InterPro IPR002933: IPR012166; KEGG: aco:Amico_0153 peptidase M20; PFAM: peptidase M20; SPTR: Peptidase M20.
       0.705
Tlie_1554
AAA ATPase; PFAM: Phosphoribulokinase / Uridine kinase family; COGs: COG0572 Uridine kinase; InterPro IPR000764: IPR003593; KEGG: tai:Taci_1361 AAA ATPase; SMART: AAA ATPase; SPTR: AAA ATPase.
   
 0.686
Tlie_1661
Putative transcriptional regulator, GntR family; PFAM: Aminotransferase class I and II; COGs: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; InterPro IPR004839; KEGG: aco:Amico_0227 putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II family protein.
     
 0.655
Tlie_0701
PFAM: SPFH domain / Band 7 family; COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR018080: IPR001107: IPR001972; KEGG: tai:Taci_0697 band 7 protein; PFAM: band 7 protein; SMART: band 7 protein; SPTR: Band 7 protein.
   
  0.641
Tlie_1664
KEGG: aco:Amico_0379 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.610
Tlie_1665
Protein of unknown function DUF6 transmembrane; PFAM: EamA-like transporter family; InterPro IPR000620; KEGG: drm:Dred_2925 hypothetical protein; PFAM: protein of unknown function DUF6 transmembrane; SPTR: Putative membrane protein.
  
    0.588
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
     
 0.546
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.522
Your Current Organism:
Thermovirga lienii
NCBI taxonomy Id: 580340
Other names: T. lienii DSM 17291, Thermovirga lienii DSM 17291, Thermovirga lienii str. DSM 17291, Thermovirga lienii strain DSM 17291
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