node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM64908.1 | EDM64909.1 | PE36_15224 | PE36_15229 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.990 |
EDM64908.1 | EDM66589.1 | PE36_15224 | PE36_15195 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.896 |
EDM64908.1 | EDM67024.1 | PE36_15224 | PE36_14124 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.836 |
EDM64908.1 | EDM67156.1 | PE36_15224 | PE36_22250 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.911 |
EDM64908.1 | EDM67220.1 | PE36_15224 | PE36_22570 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.745 |
EDM64908.1 | ilvC | PE36_15224 | PE36_15135 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.973 |
EDM64908.1 | ilvE | PE36_15224 | PE36_15219 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.954 |
EDM64908.1 | leuA-2 | PE36_15224 | PE36_22275 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | Isopropylmalate/homocitrate/citramalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.745 |
EDM64908.1 | leuB | PE36_15224 | PE36_22280 | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.900 |
EDM64909.1 | EDM64908.1 | PE36_15229 | PE36_15224 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | 0.990 |
EDM64909.1 | EDM66589.1 | PE36_15229 | PE36_15195 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.946 |
EDM64909.1 | EDM67024.1 | PE36_15229 | PE36_14124 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.931 |
EDM64909.1 | EDM67156.1 | PE36_15229 | PE36_22250 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.999 |
EDM64909.1 | EDM67220.1 | PE36_15229 | PE36_22570 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.950 |
EDM64909.1 | EDM67226.1 | PE36_15229 | PE36_22600 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 3-isopropylmalate dehydratase small subunit region; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.922 |
EDM64909.1 | ilvC | PE36_15229 | PE36_15135 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.993 |
EDM64909.1 | ilvE | PE36_15229 | PE36_15219 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.947 |
EDM64909.1 | leuA-2 | PE36_15229 | PE36_22275 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Isopropylmalate/homocitrate/citramalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.942 |
EDM64909.1 | leuB | PE36_15229 | PE36_22280 | Acetolactate synthase II large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.984 |
EDM66589.1 | EDM64908.1 | PE36_15195 | PE36_15224 | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit. | 0.896 |