node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM65667.1 | EDM65899.1 | PE36_02809 | PE36_14390 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.833 |
EDM65667.1 | EDM68187.1 | PE36_02809 | PE36_20939 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | COG2008 Threonine aldolase. | 0.805 |
EDM65667.1 | gcvP | PE36_02809 | PE36_20749 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.870 |
EDM65667.1 | gcvT | PE36_02809 | PE36_20759 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.490 |
EDM65667.1 | glyA | PE36_02809 | PE36_06023 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.541 |
EDM65667.1 | ilvA | PE36_02809 | PE36_03341 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.821 |
EDM65667.1 | ilvA-2 | PE36_02809 | PE36_15175 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Putative threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.821 |
EDM65667.1 | kbl | PE36_02809 | PE36_01407 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.575 |
EDM65667.1 | kbl-2 | PE36_02809 | PE36_20919 | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.575 |
EDM65899.1 | EDM65667.1 | PE36_14390 | PE36_02809 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Putative alcohol dehydrogenase/acetaldehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.833 |
EDM65899.1 | EDM68170.1 | PE36_14390 | PE36_20854 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | COG0498 Threonine synthase. | 0.529 |
EDM65899.1 | EDM68187.1 | PE36_14390 | PE36_20939 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | COG2008 Threonine aldolase. | 0.917 |
EDM65899.1 | gcvP | PE36_14390 | PE36_20749 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.924 |
EDM65899.1 | gcvT | PE36_14390 | PE36_20759 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.931 |
EDM65899.1 | glyA | PE36_14390 | PE36_06023 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
EDM65899.1 | ilvA | PE36_14390 | PE36_03341 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.814 |
EDM65899.1 | ilvA-2 | PE36_14390 | PE36_15175 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Putative threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.814 |
EDM65899.1 | kbl | PE36_14390 | PE36_01407 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.887 |
EDM65899.1 | kbl-2 | PE36_14390 | PE36_20919 | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.826 |
EDM68170.1 | EDM65899.1 | PE36_20854 | PE36_14390 | COG0498 Threonine synthase. | Aminotransferase, class V; COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.529 |