SIQ75858.1 protein (Microbispora rosea) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SIQ75858.1

methylglutaconyl-CoA hydratase. (266 aa)

Predicted Functional Partners:

SIS25243.1

0.963

SIQ76630.1

0.933

SIR48195.1

0.927

SIR65464.1

0.927

SIR90934.1

0.923

SIQ75831.1

0.855

rpsI

0.819

rpsP

0.817

rplQ

0.807

SIQ75885.1

0.805

Your Current Organism:

Microbispora rosea

NCBI taxonomy Id: 58117
Other names: ATCC 12950, DSM 43839, IFO 14044, JCM 3006, M. rosea, NBRC 14044, NRRL B-2632, VKM Ac-634, Waksmania rosea

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIQ75831.1	SIQ75858.1	SAMN05421833_103363	SAMN05421833_103364	propionyl-CoA carboxylase alpha chain.	methylglutaconyl-CoA hydratase.	0.855
SIQ75831.1	SIQ75885.1	SAMN05421833_103363	SAMN05421833_103365	propionyl-CoA carboxylase alpha chain.	Protein of unknown function.	0.884
SIQ75831.1	SIQ76630.1	SAMN05421833_103363	SAMN05421833_103389	propionyl-CoA carboxylase alpha chain.	3-methylcrotonyl-CoA carboxylase beta subunit.	0.961
SIQ75858.1	SIQ75831.1	SAMN05421833_103364	SAMN05421833_103363	methylglutaconyl-CoA hydratase.	propionyl-CoA carboxylase alpha chain.	0.855
SIQ75858.1	SIQ75885.1	SAMN05421833_103364	SAMN05421833_103365	methylglutaconyl-CoA hydratase.	Protein of unknown function.	0.805
SIQ75858.1	SIQ76630.1	SAMN05421833_103364	SAMN05421833_103389	methylglutaconyl-CoA hydratase.	3-methylcrotonyl-CoA carboxylase beta subunit.	0.933
SIQ75858.1	SIR48195.1	SAMN05421833_103364	SAMN05421833_109237	methylglutaconyl-CoA hydratase.	Signal transduction histidine kinase.	0.927
SIQ75858.1	SIR65464.1	SAMN05421833_103364	SAMN05421833_112120	methylglutaconyl-CoA hydratase.	GAF sensor hybrid histidine kinase.	0.927
SIQ75858.1	SIR90934.1	SAMN05421833_103364	SAMN05421833_11975	methylglutaconyl-CoA hydratase.	Signal transduction histidine kinase.	0.923
SIQ75858.1	SIS25243.1	SAMN05421833_103364	SAMN05421833_1647	methylglutaconyl-CoA hydratase.	PAS/PAC sensor signal transduction histidine kinase.	0.963
SIQ75858.1	rplQ	SAMN05421833_103364	SAMN05421833_10238	methylglutaconyl-CoA hydratase.	LSU ribosomal protein L17P.	0.807
SIQ75858.1	rpsI	SAMN05421833_103364	SAMN05421833_10245	methylglutaconyl-CoA hydratase.	SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family.	0.819
SIQ75858.1	rpsP	SAMN05421833_103364	SAMN05421833_108192	methylglutaconyl-CoA hydratase.	Small subunit ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.	0.817
SIQ75885.1	SIQ75831.1	SAMN05421833_103365	SAMN05421833_103363	Protein of unknown function.	propionyl-CoA carboxylase alpha chain.	0.884
SIQ75885.1	SIQ75858.1	SAMN05421833_103365	SAMN05421833_103364	Protein of unknown function.	methylglutaconyl-CoA hydratase.	0.805
SIQ75885.1	SIQ76630.1	SAMN05421833_103365	SAMN05421833_103389	Protein of unknown function.	3-methylcrotonyl-CoA carboxylase beta subunit.	0.559
SIQ76630.1	SIQ75831.1	SAMN05421833_103389	SAMN05421833_103363	3-methylcrotonyl-CoA carboxylase beta subunit.	propionyl-CoA carboxylase alpha chain.	0.961
SIQ76630.1	SIQ75858.1	SAMN05421833_103389	SAMN05421833_103364	3-methylcrotonyl-CoA carboxylase beta subunit.	methylglutaconyl-CoA hydratase.	0.933
SIQ76630.1	SIQ75885.1	SAMN05421833_103389	SAMN05421833_103365	3-methylcrotonyl-CoA carboxylase beta subunit.	Protein of unknown function.	0.559
SIR48195.1	SIQ75858.1	SAMN05421833_109237	SAMN05421833_103364	Signal transduction histidine kinase.	methylglutaconyl-CoA hydratase.	0.927

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

43

PPI enrichment p-value:

0.325

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 53

1.58

1.99

7.04e-06

GO:0050896

Response to stimulus

9 of 315

0.98

1.04

7.04e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

6 of 61

1.52

1.88

8.42e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 234

1.0

0.94

0.00017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2982

PAS domain superfamily, and GAF domain

9 of 31

1.99

5.18

3.35e-14

CL:2985

PAS domain

7 of 20

2.07

4.67

1.24e-11

CL:2986

PAS fold-4, and Signal transduction histidine kinase, phosphotransfer (Hpt) domain

6 of 15

2.13

4.29

3.52e-10

CL:2991

PAS fold-4, and Histidine Phosphotransfer domain

3 of 10

2.0

1.83

0.00021

CL:2994

Mixed, incl. Phytochrome chromophore attachment domain, and CheB methylesterase

2 of 5

2.13

1.18

0.0060

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 346

0.94

1.0

3.51e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

6 of 70

1.46

1.83

5.91e-06

KW-0418

Kinase

6 of 120

1.23

1.29

6.27e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 53

1.71

3.2

7.79e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 56

1.68

3.14

7.79e-10

IPR005467

Histidine kinase domain

8 of 58

1.67

3.09

7.79e-10

IPR035965

PAS domain superfamily

8 of 59

1.66

3.07

7.79e-10

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 67

1.6

2.91

8.84e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

8 of 57

1.67

3.29

1.11e-10

SM00091

PAS domain

7 of 57

1.62

2.77

6.22e-09

SM00387

Histidine kinase-like ATPases

7 of 60

1.59

2.72

6.22e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

6 of 43

1.67

2.69

5.21e-08

SM00448

cheY-homologous receiver domain

6 of 58

1.54

2.28

2.20e-07

(more ...)

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