node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIQ68954.1 | SIS08065.1 | SAMN05421833_103151 | SAMN05421833_12673 | Curved DNA-binding protein. | MerR family transcriptional regulator, heat shock protein HspR. | 0.764 |
SIQ68954.1 | dnaK | SAMN05421833_103151 | SAMN05421833_103149 | Curved DNA-binding protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
SIQ68954.1 | dnaK-2 | SAMN05421833_103151 | SAMN05421833_12670 | Curved DNA-binding protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.995 |
SIQ68954.1 | groL | SAMN05421833_103151 | SAMN05421833_10275 | Curved DNA-binding protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.759 |
SIQ68954.1 | groL-2 | SAMN05421833_103151 | SAMN05421833_123116 | Curved DNA-binding protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.757 |
SIQ68954.1 | groS | SAMN05421833_103151 | SAMN05421833_10274 | Curved DNA-binding protein. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.656 |
SIQ68954.1 | grpE-2 | SAMN05421833_103151 | SAMN05421833_12671 | Curved DNA-binding protein. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.931 |
SIQ68954.1 | hrcA | SAMN05421833_103151 | SAMN05421833_11791 | Curved DNA-binding protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.759 |
SIS08065.1 | SIQ68954.1 | SAMN05421833_12673 | SAMN05421833_103151 | MerR family transcriptional regulator, heat shock protein HspR. | Curved DNA-binding protein. | 0.764 |
SIS08065.1 | dnaJ | SAMN05421833_12673 | SAMN05421833_11792 | MerR family transcriptional regulator, heat shock protein HspR. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.764 |
SIS08065.1 | dnaJ-2 | SAMN05421833_12673 | SAMN05421833_12672 | MerR family transcriptional regulator, heat shock protein HspR. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.944 |
SIS08065.1 | dnaK | SAMN05421833_12673 | SAMN05421833_103149 | MerR family transcriptional regulator, heat shock protein HspR. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.701 |
SIS08065.1 | dnaK-2 | SAMN05421833_12673 | SAMN05421833_12670 | MerR family transcriptional regulator, heat shock protein HspR. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.843 |
SIS08065.1 | groL | SAMN05421833_12673 | SAMN05421833_10275 | MerR family transcriptional regulator, heat shock protein HspR. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.500 |
SIS08065.1 | groL-2 | SAMN05421833_12673 | SAMN05421833_123116 | MerR family transcriptional regulator, heat shock protein HspR. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.500 |
SIS08065.1 | groS | SAMN05421833_12673 | SAMN05421833_10274 | MerR family transcriptional regulator, heat shock protein HspR. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.539 |
SIS08065.1 | grpE-2 | SAMN05421833_12673 | SAMN05421833_12671 | MerR family transcriptional regulator, heat shock protein HspR. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.948 |
SIS08065.1 | hrcA | SAMN05421833_12673 | SAMN05421833_11791 | MerR family transcriptional regulator, heat shock protein HspR. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.743 |
dnaJ | SIS08065.1 | SAMN05421833_11792 | SAMN05421833_12673 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | MerR family transcriptional regulator, heat shock protein HspR. | 0.764 |
dnaJ | dnaK | SAMN05421833_11792 | SAMN05421833_103149 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.995 |