STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIS10120.1DNA-binding transcriptional activator of the SARP family. (932 aa)    
Predicted Functional Partners:
SIR48195.1
Signal transduction histidine kinase.
   
 0.768
SIR65464.1
GAF sensor hybrid histidine kinase.
   
 0.768
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
  0.733
SIS22951.1
PAS domain S-box-containing protein.
  
 0.649
ribBA
GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.610
SIS25243.1
PAS/PAC sensor signal transduction histidine kinase.
   
 0.588
SIR38172.1
Nitrogen regulatory protein P-II family.
    
 
 0.583
SIQ74489.1
Helix-turn-helix domain-containing protein.
  
    0.547
SIR43191.1
Helix-turn-helix domain-containing protein.
  
    0.545
SIR77314.1
Helix-turn-helix domain-containing protein.
  
    0.541
Your Current Organism:
Microbispora rosea
NCBI taxonomy Id: 58117
Other names: ATCC 12950, DSM 43839, IFO 14044, JCM 3006, M. rosea, NBRC 14044, NRRL B-2632, VKM Ac-634, Waksmania rosea
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.