SIS09414.1 protein (Microbispora rosea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SIS09414.1

Formate-dependent nitrite reductase, membrane component NrfD. (311 aa)

Predicted Functional Partners:

SIS09406.1

0.979

SIS09395.1

0.965

SIS09387.1

0.938

SIS09521.1

0.834

selA

0.782

selD

0.740

SIQ99816.1

0.595

SIR86581.1

0.595

SIQ23168.1

0.530

SIR47993.1

0.477

Your Current Organism:

Microbispora rosea

NCBI taxonomy Id: 58117
Other names: ATCC 12950, DSM 43839, IFO 14044, JCM 3006, M. rosea, NBRC 14044, NRRL B-2632, VKM Ac-634, Waksmania rosea

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIQ23168.1	SIQ99816.1	SAMN05421833_101216	SAMN05421833_10594	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	Glyoxylase, beta-lactamase superfamily II.	0.423
SIQ23168.1	SIR86581.1	SAMN05421833_101216	SAMN05421833_117175	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	Glyoxylase, beta-lactamase superfamily II.	0.423
SIQ23168.1	SIS09387.1	SAMN05421833_101216	SAMN05421833_1278	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	Formate dehydrogenase major subunit.	0.963
SIQ23168.1	SIS09395.1	SAMN05421833_101216	SAMN05421833_1279	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.963
SIQ23168.1	SIS09406.1	SAMN05421833_101216	SAMN05421833_12710	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	Formate dehydrogenase beta subunit.	0.986
SIQ23168.1	SIS09414.1	SAMN05421833_101216	SAMN05421833_12711	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	Formate-dependent nitrite reductase, membrane component NrfD.	0.530
SIQ99816.1	SIQ23168.1	SAMN05421833_10594	SAMN05421833_101216	Glyoxylase, beta-lactamase superfamily II.	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	0.423
SIQ99816.1	SIR86581.1	SAMN05421833_10594	SAMN05421833_117175	Glyoxylase, beta-lactamase superfamily II.	Glyoxylase, beta-lactamase superfamily II.	0.919
SIQ99816.1	SIS09387.1	SAMN05421833_10594	SAMN05421833_1278	Glyoxylase, beta-lactamase superfamily II.	Formate dehydrogenase major subunit.	0.872
SIQ99816.1	SIS09395.1	SAMN05421833_10594	SAMN05421833_1279	Glyoxylase, beta-lactamase superfamily II.	Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.872
SIQ99816.1	SIS09406.1	SAMN05421833_10594	SAMN05421833_12710	Glyoxylase, beta-lactamase superfamily II.	Formate dehydrogenase beta subunit.	0.672
SIQ99816.1	SIS09414.1	SAMN05421833_10594	SAMN05421833_12711	Glyoxylase, beta-lactamase superfamily II.	Formate-dependent nitrite reductase, membrane component NrfD.	0.595
SIR47993.1	SIS09414.1	SAMN05421833_109227	SAMN05421833_12711	GAF domain-containing protein.	Formate-dependent nitrite reductase, membrane component NrfD.	0.477
SIR86581.1	SIQ23168.1	SAMN05421833_117175	SAMN05421833_101216	Glyoxylase, beta-lactamase superfamily II.	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	0.423
SIR86581.1	SIQ99816.1	SAMN05421833_117175	SAMN05421833_10594	Glyoxylase, beta-lactamase superfamily II.	Glyoxylase, beta-lactamase superfamily II.	0.919
SIR86581.1	SIS09387.1	SAMN05421833_117175	SAMN05421833_1278	Glyoxylase, beta-lactamase superfamily II.	Formate dehydrogenase major subunit.	0.872
SIR86581.1	SIS09395.1	SAMN05421833_117175	SAMN05421833_1279	Glyoxylase, beta-lactamase superfamily II.	Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.872
SIR86581.1	SIS09406.1	SAMN05421833_117175	SAMN05421833_12710	Glyoxylase, beta-lactamase superfamily II.	Formate dehydrogenase beta subunit.	0.672
SIR86581.1	SIS09414.1	SAMN05421833_117175	SAMN05421833_12711	Glyoxylase, beta-lactamase superfamily II.	Formate-dependent nitrite reductase, membrane component NrfD.	0.595
SIS09387.1	SIQ23168.1	SAMN05421833_1278	SAMN05421833_101216	Formate dehydrogenase major subunit.	Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor.	0.963

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.88

expected number of edges:

17

PPI enrichment p-value:

0.00603

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006560

Proline metabolic process

4 of 4

2.5

3.05

1.60e-06

GO:0009084

Glutamine family amino acid biosynthetic process

6 of 24

1.89

3.02

1.01e-07

GO:0009064

Glutamine family amino acid metabolic process

7 of 51

1.63

2.54

1.01e-07

GO:0055129

L-proline biosynthetic process

3 of 3

2.5

2.21

7.42e-05

GO:0006520

Cellular amino acid metabolic process

8 of 189

1.12

1.29

4.32e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

10 of 1172

0.43

0.31

0.0189

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1183

Proline biosynthesis, and Cyclic nucleotide metabolic process

3 of 5

2.27

1.57

0.0011

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

4 of 31

1.61

1.58

0.00021

map00332

Carbapenem biosynthesis

2 of 2

2.5

1.42

0.0024

map01230

Biosynthesis of amino acids

6 of 135

1.14

1.1

0.00021

map01110

Biosynthesis of secondary metabolites

7 of 486

0.65

0.47

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0641

Proline biosynthesis

3 of 3

2.5

2.15

9.78e-05

KW-0028

Amino-acid biosynthesis

4 of 54

1.36

1.1

0.0019

KW-0963

Cytoplasm

6 of 207

0.96

0.77

0.0019

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About