SIS09599.1 protein (Microbispora rosea) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:

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Score

SIS09599.1

Glycosyltransferase like family 2. (367 aa)

Predicted Functional Partners:

SIS09606.1

0.797

SIS09615.1

0.773

SIR74340.1

0.724

SIS09622.1

0.576

SIR54740.1

0.541

SIR79489.1

0.501

SIR70383.1

0.480

SIR13299.1

0.463

SIS25191.1

0.449

SIS22951.1

0.443

Your Current Organism:

Microbispora rosea

NCBI taxonomy Id: 58117
Other names: ATCC 12950, DSM 43839, IFO 14044, JCM 3006, M. rosea, NBRC 14044, NRRL B-2632, VKM Ac-634, Waksmania rosea

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIR13299.1	SIR70383.1	SAMN05421833_106120	SAMN05421833_113107	Endoglucanase.	Alpha-1,6-glucosidases, pullulanase-type; Belongs to the glycosyl hydrolase 13 family.	0.799
SIR13299.1	SIR79489.1	SAMN05421833_106120	SAMN05421833_115191	Endoglucanase.	Polysaccharide deacetylase.	0.745
SIR13299.1	SIS09599.1	SAMN05421833_106120	SAMN05421833_12734	Endoglucanase.	Glycosyltransferase like family 2.	0.463
SIR13299.1	SIS25191.1	SAMN05421833_106120	SAMN05421833_1624	Endoglucanase.	Glucose/arabinose dehydrogenase, beta-propeller fold.	0.560
SIR54740.1	SIR74340.1	SAMN05421833_110176	SAMN05421833_114107	Flp pilus assembly protein TadD, contains TPR repeats.	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	0.623
SIR54740.1	SIS09599.1	SAMN05421833_110176	SAMN05421833_12734	Flp pilus assembly protein TadD, contains TPR repeats.	Glycosyltransferase like family 2.	0.541
SIR54740.1	SIS22951.1	SAMN05421833_110176	SAMN05421833_14526	Flp pilus assembly protein TadD, contains TPR repeats.	PAS domain S-box-containing protein.	0.904
SIR70383.1	SIR13299.1	SAMN05421833_113107	SAMN05421833_106120	Alpha-1,6-glucosidases, pullulanase-type; Belongs to the glycosyl hydrolase 13 family.	Endoglucanase.	0.799
SIR70383.1	SIS09599.1	SAMN05421833_113107	SAMN05421833_12734	Alpha-1,6-glucosidases, pullulanase-type; Belongs to the glycosyl hydrolase 13 family.	Glycosyltransferase like family 2.	0.480
SIR70383.1	SIS25191.1	SAMN05421833_113107	SAMN05421833_1624	Alpha-1,6-glucosidases, pullulanase-type; Belongs to the glycosyl hydrolase 13 family.	Glucose/arabinose dehydrogenase, beta-propeller fold.	0.516
SIR74340.1	SIR54740.1	SAMN05421833_114107	SAMN05421833_110176	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Flp pilus assembly protein TadD, contains TPR repeats.	0.623
SIR74340.1	SIS09599.1	SAMN05421833_114107	SAMN05421833_12734	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	Glycosyltransferase like family 2.	0.724
SIR74340.1	SIS22951.1	SAMN05421833_114107	SAMN05421833_14526	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	PAS domain S-box-containing protein.	0.999
SIR79489.1	SIR13299.1	SAMN05421833_115191	SAMN05421833_106120	Polysaccharide deacetylase.	Endoglucanase.	0.745
SIR79489.1	SIS09599.1	SAMN05421833_115191	SAMN05421833_12734	Polysaccharide deacetylase.	Glycosyltransferase like family 2.	0.501
SIS09599.1	SIR13299.1	SAMN05421833_12734	SAMN05421833_106120	Glycosyltransferase like family 2.	Endoglucanase.	0.463
SIS09599.1	SIR54740.1	SAMN05421833_12734	SAMN05421833_110176	Glycosyltransferase like family 2.	Flp pilus assembly protein TadD, contains TPR repeats.	0.541
SIS09599.1	SIR70383.1	SAMN05421833_12734	SAMN05421833_113107	Glycosyltransferase like family 2.	Alpha-1,6-glucosidases, pullulanase-type; Belongs to the glycosyl hydrolase 13 family.	0.480
SIS09599.1	SIR74340.1	SAMN05421833_12734	SAMN05421833_114107	Glycosyltransferase like family 2.	PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.	0.724
SIS09599.1	SIR79489.1	SAMN05421833_12734	SAMN05421833_115191	Glycosyltransferase like family 2.	Polysaccharide deacetylase.	0.501

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

148

PPI enrichment p-value:

0.633

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

8 of 68

1.92

4.25

1.36e-11

GO:0019752

Carboxylic acid metabolic process

9 of 566

1.05

1.24

4.41e-07

GO:0044249

Cellular biosynthetic process

9 of 1106

0.76

0.68

0.00010

GO:1901576

Organic substance biosynthetic process

9 of 1134

0.75

0.67

0.00012

GO:0044238

Primary metabolic process

10 of 2411

0.47

0.36

0.0052

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

8 of 27

2.32

6.41

9.88e-15

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

8 of 28

2.31

6.37

9.88e-15

GO:0019842

Vitamin binding

9 of 101

1.8

4.31

1.23e-13

GO:0003824

Catalytic activity

11 of 3751

0.32

0.25

0.0258

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1386

Phosphopantetheine binding, and Condensation domain

9 of 27

2.37

7.5

2.99e-17

CL:1389

Phosphopantetheine binding, and Condensation domain

7 of 21

2.37

6.07

1.58e-13

CL:1366

Mixed, incl. Phosphopantetheine, and Fatty acid biosynthesis

10 of 132

1.73

4.23

7.68e-15

CL:1391

Phosphopantetheine binding

4 of 12

2.37

3.25

4.69e-07

CL:1418

Erythronolide synthase docking domain, and Phosphopantetheine attachment site

2 of 5

2.45

1.29

0.0043

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00660

C5-Branched dibasic acid metabolism

2 of 16

1.95

0.74

0.0405

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034081

Polyketide synthase complex

8 of 26

2.34

6.65

3.01e-15

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

9 of 54

2.07

5.9

1.03e-15

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16197

Ketoacyl-synthetase C-terminal extension

4 of 6

2.67

3.42

3.96e-07

PF00550

Phosphopantetheine attachment site

5 of 33

2.03

2.98

4.18e-07

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 6

2.55

2.3

5.14e-05

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 11

2.29

1.98

0.00017

PF14765

Polyketide synthase dehydratase

2 of 2

2.85

1.51

0.0018

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

6 of 10

2.63

5.97

2.19e-12

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

6 of 10

2.63

5.97

2.19e-12

SM00823

Phosphopantetheine attachment site

4 of 13

2.34

3.31

3.12e-07

SM00825

Beta-ketoacyl synthase

3 of 6

2.55

2.71

8.08e-06

SM00826

PKS_DH

2 of 6

2.37

1.46

0.0019

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