STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PBANKA_0610800Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (630 aa)    
Predicted Functional Partners:
PBANKA_1232500
Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family.
   
 
 0.862
PBANKA_0928100
Phosphoglycerate mutase.
   
  
 0.617
PBANKA_0710100
2-oxoglutarate dehydrogenase E1 component, putative.
      
 0.568
PBANKA_1440700
Ubiquitin-activating enzyme E1, putative.
   
  
 0.554
PBANKA_0938500
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
      
 0.543
PBANKA_1016200
Protein kinase, putative.
   
 
 0.479
PBANKA_1308400
Eukaryotic translation initiation factor 2-alpha kinase 1, putative.
   
 
 0.479
PBANKA_1031900
Eukaryotic translation initiation factor 2 subunit gamma, putative.
   
 
 0.441
PBANKA_0521400
Serine/threonine protein kinase RIO2, putative.
   
   0.439
PBANKA_0834800
Histidine--tRNA ligase, putative.
   
 
 0.438
Your Current Organism:
Plasmodium berghei
NCBI taxonomy Id: 5823
Other names: P. berghei ANKA, Plasmodium berghei (strain ANKA), Plasmodium berghei ANKA, Plasmodium berghei str. ANKA, Plasmodium berghei strain ANKA
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.