node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | guaA | Hbal_0751 | Hbal_1810 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.997 |
apt | guaB | Hbal_0751 | Hbal_1816 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.547 |
apt | pyrG | Hbal_0751 | Hbal_1692 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.504 |
argS | guaA | Hbal_1048 | Hbal_1810 | KEGG: ccs:CCNA_03469 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.996 |
argS | pyrG | Hbal_1048 | Hbal_1692 | KEGG: ccs:CCNA_03469 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.844 |
argS | rplA | Hbal_1048 | Hbal_2093 | KEGG: ccs:CCNA_03469 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.603 |
argS | rplK | Hbal_1048 | Hbal_2094 | KEGG: ccs:CCNA_03469 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.553 |
argS | truB | Hbal_1048 | Hbal_3066 | KEGG: ccs:CCNA_03469 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.523 |
argS | tuf | Hbal_1048 | Hbal_2085 | KEGG: ccs:CCNA_03469 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.412 |
guaA | apt | Hbal_1810 | Hbal_0751 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.997 |
guaA | argS | Hbal_1810 | Hbal_1048 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | KEGG: ccs:CCNA_03469 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | 0.996 |
guaA | guaB | Hbal_1810 | Hbal_1816 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | map | Hbal_1810 | Hbal_0615 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.972 |
guaA | map-2 | Hbal_1810 | Hbal_1253 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.972 |
guaA | pyrG | Hbal_1810 | Hbal_1692 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.989 |
guaA | rplA | Hbal_1810 | Hbal_2093 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.978 |
guaA | rplK | Hbal_1810 | Hbal_2094 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.991 |
guaA | truB | Hbal_1810 | Hbal_3066 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.974 |
guaA | tuf | Hbal_1810 | Hbal_2085 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.979 |
guaB | apt | Hbal_1816 | Hbal_0751 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.547 |