Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Hden_0010PFAM: protein of unknown function DUF45; KEGG: azc:AZC_4690 hypothetical protein. (282 aa)    
Predicted Functional Partners:
Hden_0011
PFAM: electron transport protein SCO1/SenC; KEGG: pla:Plav_0014 classical-complement-pathway C3/C5 convertase.
       0.601
Hden_0012
Integral membrane sensor signal transduction histidine kinase; KEGG: mlo:mlr5307 two-component, sensor histidine protein kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein.
       0.484
Hden_0013
Response regulator receiver protein; KEGG: pla:Plav_0018 two component Fis family transcriptional regulator; PFAM: response regulator receiver; SMART: response regulator receiver.
  
    0.406
Your Current Organism:
Hyphomicrobium denitrificans ATCC 51888
NCBI taxonomy Id: 582899
Other names: H. denitrificans ATCC 51888, Hyphomicrobium denitrificans str. ATCC 51888, Hyphomicrobium denitrificans strain ATCC 51888
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