STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccmECcmE/CycJ protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (155 aa)    
Predicted Functional Partners:
ccmC
Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
 
 0.989
Hden_1131
KEGG: sme:SMc02363 cytochrome c-type biogenesis transmembrane protein; TIGRFAM: cytochrome c-type biogenesis protein CcmF; PFAM: cytochrome c assembly protein.
 
 
 0.978
Hden_1132
Cytochrome C biogenesis protein; Possible subunit of a heme lyase.
 
  
 0.969
Hden_1129
KEGG: sme:SMc02361 cytochrome c-type biogenesis transmembrane protein; TIGRFAM: cytochrome c-type biogenesis protein CcmI; SMART: Tetratricopeptide repeat.
 
  
 0.942
Hden_3251
Heme exporter protein CcmB; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
 
 0.923
Hden_3247
Periplasmic protein thiol/disulfide oxidoreductase DsbE; KEGG: bmr:BMI_I101 thiol:disulfide interchange protein, thioredoxin family; TIGRFAM: periplasmic protein thiol/disulphide oxidoreductase DsbE; PFAM: Redoxin domain protein.
 
  
 0.893
ccmA
Heme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
 
 0.791
Hden_1605
PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; cytochrome c biogenesis protein transmembrane region; KEGG: bxe:Bxe_B0816 putative transmembrane protein.
  
  
 0.593
glnE
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
  
    0.521
Hden_1128
PFAM: 17 kDa surface antigen; KEGG: pla:Plav_0789 17 kDa surface antigen.
       0.503
Your Current Organism:
Hyphomicrobium denitrificans ATCC 51888
NCBI taxonomy Id: 582899
Other names: H. denitrificans ATCC 51888, Hyphomicrobium denitrificans str. ATCC 51888, Hyphomicrobium denitrificans strain ATCC 51888
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