Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rnhB-2Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (274 aa)    
Predicted Functional Partners:
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
  
 
0.910
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 0.859
Hden_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.855
Hden_0527
PFAM: Soluble ligand binding domain; KEGG: nhl:Nhal_2430 respiratory-chain NADH dehydrogenase domain 51 kDa subunit.
    
   0.762
Hden_2571
TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; PFAM: RQC domain; DEAD/DEAH box helicase domain protein; helicase domain protein; HRDC domain protein; KEGG: tgr:Tgr7_1931 ATP-dependent DNA helicase RecQ; SMART: DEAD-like helicase; helicase domain protein; HRDC domain protein.
  
 
 0.754
rnhA
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.713
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.668
Hden_2665
AMP-dependent synthetase and ligase; KEGG: bja:bll2324 acylglycerophosphoethanolamine acyltransferase; PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase.
  
 
 0.650
lpxB
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
  
 0.630
Hden_3206
KEGG: oca:OCAR_7084 hypothetical protein.
       0.618
Your Current Organism:
Hyphomicrobium denitrificans ATCC 51888
NCBI taxonomy Id: 582899
Other names: H. denitrificans ATCC 51888, Hyphomicrobium denitrificans str. ATCC 51888, Hyphomicrobium denitrificans strain ATCC 51888
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