STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
rtcARNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (353 aa)    
Predicted Functional Partners:
rps4
SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 0.958
rps6e
COGs: COG2125 Ribosomal protein S6E (S10); InterPro IPR001377:IPR018282; KEGG: hbu:Hbut_0442 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; SPTR: A2BJZ7 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
    
  0.952
rps11
SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
    
  0.943
csl4
RNA-binding S1 domain-containing protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
  
  0.935
Igag_0023
COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR002687:IPR012976; KEGG: hbu:Hbut_0030 ribosomal biogenesis protein - Nop56/SIK1; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; SPTR: A2BIV2 Ribosomal biogenesis protein-Nop56/SIK1; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain.
 
 
 0.934
rps3ae
COGs: COG1890 Ribosomal protein S3AE; InterPro IPR001593:IPR018281; KEGG: hbu:Hbut_0428 30S ribosomal protein S3Ae; PFAM: ribosomal protein S3Ae; SPTR: A2BJY3 30S ribosomal protein S3Ae; PFAM: Ribosomal S3Ae family; Belongs to the eukaryotic ribosomal protein eS1 family.
  
 
  0.917
Igag_1111
KH domain protein; COGs: COG1094 RNA-binding protein (contains KH domains); InterPro IPR018111:IPR004087:IPR004088:IPR019964; KEGG: hbu:Hbut_1405 putative RNA-processing protein; PFAM: K Homology, type 1, subgroup; SMART: KH domain protein; SPTR: A2BML8 Universally conserved protein; TIGRFAM: KH domain protein; PFAM: KH domain; TIGRFAM: arCOG04150 universal archaeal KH domain protein.
   
 
 0.916
tmcA
Protein of unknown function DUF699 ATPase putative; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
   
 
 0.916
nep1
Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
   
 
 0.909
rrp4
Exosome complex RNA-binding protein Rrp4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
   
  0.899
Your Current Organism:
Ignisphaera aggregans
NCBI taxonomy Id: 583356
Other names: I. aggregans DSM 17230, Ignisphaera aggregans DSM 17230, Ignisphaera aggregans str. DSM 17230, Ignisphaera aggregans strain DSM 17230
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