STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Igag_0563HhH-GPD family protein; COGs: COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; InterPro IPR003265; KEGG: pcl:Pcal_1250 hypothetical protein; SMART: HhH-GPD family protein; SPTR: A3MVK7 Putative uncharacterized protein; PFAM: HhH-GPD superfamily base excision DNA repair protein. (328 aa)    
Predicted Functional Partners:
Igag_0562
Hypothetical protein.
       0.631
Igag_1975
COGs: COG0648 Endonuclease IV; InterPro IPR012307:IPR001719; KEGG: dka:DKAM_0986 endonuclease IV; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2; SPTR: B8D5D1 Endonuclease IV; PFAM: Xylose isomerase-like TIM barrel.
   
 
 0.578
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
 
 
 
 0.569
Igag_0564
Protein of unknown function DUF1626; InterPro IPR012431; KEGG: tpe:Tpen_1705 hypothetical protein; PFAM: Protein of unknown function DUF1626; SPTR: A1S0X0 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1626).
       0.552
Igag_0389
methylated-DNA/protein- cysteinemethyltransferase; COGs: COG0350 Methylated DNA-protein cysteine methyltransferase; InterPro IPR014048:IPR001497; KEGG: smr:Smar_0042 methylated-DNA--protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; SPTR: A3DKJ5 Methylated-DNA--protein-cysteine methyltransferase; TIGRFAM: methylated-DNA/protein-cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain; TIGRFAM: O-6-methylguanine DNA methyltransferase.
  
  
 0.497
Igag_1927
HhH-GPD family protein; COGs: COG0177 EndoIII-related endonuclease; InterPro IPR003265:IPR003651:IPR004035; KEGG: smr:Smar_1371 HhH-GPD family protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; SPTR: A3DPA2 HhH-GPD family protein; PFAM: HhH-GPD superfamily base excision DNA repair protein.
   
 
 0.493
Igag_0728
Helicase domain protein; COGs: COG1111 ERCC4-like helicase; InterProIPR000330:IPR001650:IPR006935:IPR014001:IPR 014021; KEGG: kcr:Kcr_0700 helicase domain-containing protein; PFAM: helicase domain protein; SNF2-related protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; SPTR: B1L4S2 Helicase domain protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
   
 
 0.448
Igag_1027
COGs: COG4021 conserved hypothetical protein; KEGG: hbu:Hbut_1048 hypothetical protein; SPTR: A2BLN1 Conserved archaeal protein; PFAM: tRNAHis guanylyltransferase.
  
    0.436
Igag_0138
AAA ATPase; InterPro IPR003593; KEGG: smr:Smar_0618 AAA ATPase; SMART: AAA ATPase; SPTR: A3DM65 AAA ATPase.
    
 
 0.435
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
    
 
 0.435
Your Current Organism:
Ignisphaera aggregans
NCBI taxonomy Id: 583356
Other names: I. aggregans DSM 17230, Ignisphaera aggregans DSM 17230, Ignisphaera aggregans str. DSM 17230, Ignisphaera aggregans strain DSM 17230
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