Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADH59924.1KEGG: tpd:Teth39_2153 DNA-3-methyladenine glycosylase I; PFAM: methyladenine glycosylase. (190 aa)    
Predicted Functional Partners:
ADH59923.1
PFAM: ROK family protein; KEGG: tpd:Teth39_2154 ROK family glucokinase.
       0.764
ADH61781.1
methylated-DNA/protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
    
 0.697
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.633
ADH59925.1
PFAM: Sigma-G inhibitor, Gin; KEGG: tpd:Teth39_2152 hypothetical protein.
       0.490
cinA
Competence/damage-inducible protein CinA; KEGG: tpd:Teth39_1192 competence damage-inducible protein A; TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; Belongs to the CinA family.
  
    0.464
ADH59922.1
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: tpd:Teth39_2155 FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
    0.420
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
       0.417
ADH59928.1
PFAM: protein of unknown function DUF970; KEGG: tpd:Teth39_2149 hypothetical protein.
       0.410
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
       0.404
ADH59930.1
TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: tpd:Teth39_2147 DNA polymerase III, delta prime subunit.
       0.400
Your Current Organism:
Thermoanaerobacter mathranii
NCBI taxonomy Id: 583358
Other names: T. mathranii subsp. mathranii str. A3, Thermoanaerobacter mathranii subsp. mathranii A3, Thermoanaerobacter mathranii subsp. mathranii DSM 11426, Thermoanaerobacter mathranii subsp. mathranii str. A3, Thermoanaerobacter mathranii subsp. mathranii strain A3
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