| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADH59936.1 | ADH60871.1 | Tmath_0152 | Tmath_1153 | KEGG: tpd:Teth39_2141 AbrB family transcriptional regulator; TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein. | Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.779 |
| ADH59936.1 | spoIIAB | Tmath_0152 | Tmath_1166 | KEGG: tpd:Teth39_2141 AbrB family transcriptional regulator; TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein. | Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.655 |
| ADH59936.1 | spoVG | Tmath_0152 | Tmath_2147 | KEGG: tpd:Teth39_2141 AbrB family transcriptional regulator; TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein. | SpoVG family protein; Could be involved in septation. | 0.436 |
| ADH60871.1 | ADH59936.1 | Tmath_1153 | Tmath_0152 | Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | KEGG: tpd:Teth39_2141 AbrB family transcriptional regulator; TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein. | 0.779 |
| ADH60871.1 | spoIIAB | Tmath_1153 | Tmath_1166 | Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.824 |
| ADH60871.1 | spoVG | Tmath_1153 | Tmath_2147 | Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | SpoVG family protein; Could be involved in septation. | 0.457 |
| ADH61820.1 | glmU | Tmath_2148 | Tmath_2146 | KEGG: tpd:Teth39_0159 pur operon repressor; TIGRFAM: pur operon repressor; PFAM: purine repressor; phosphoribosyltransferase. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.738 |
| ADH61820.1 | murC | Tmath_2148 | Tmath_2149 | KEGG: tpd:Teth39_0159 pur operon repressor; TIGRFAM: pur operon repressor; PFAM: purine repressor; phosphoribosyltransferase. | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.693 |
| ADH61820.1 | prs | Tmath_2148 | Tmath_2145 | KEGG: tpd:Teth39_0159 pur operon repressor; TIGRFAM: pur operon repressor; PFAM: purine repressor; phosphoribosyltransferase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.677 |
| ADH61820.1 | pth | Tmath_2148 | Tmath_2141 | KEGG: tpd:Teth39_0159 pur operon repressor; TIGRFAM: pur operon repressor; PFAM: purine repressor; phosphoribosyltransferase. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.400 |
| ADH61820.1 | spoVG | Tmath_2148 | Tmath_2147 | KEGG: tpd:Teth39_0159 pur operon repressor; TIGRFAM: pur operon repressor; PFAM: purine repressor; phosphoribosyltransferase. | SpoVG family protein; Could be involved in septation. | 0.659 |
| glmU | ADH61820.1 | Tmath_2146 | Tmath_2148 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | KEGG: tpd:Teth39_0159 pur operon repressor; TIGRFAM: pur operon repressor; PFAM: purine repressor; phosphoribosyltransferase. | 0.738 |
| glmU | murC | Tmath_2146 | Tmath_2149 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.847 |
| glmU | prs | Tmath_2146 | Tmath_2145 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.973 |
| glmU | pth | Tmath_2146 | Tmath_2141 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.530 |
| glmU | spoVG | Tmath_2146 | Tmath_2147 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | SpoVG family protein; Could be involved in septation. | 0.674 |
| gyrB | smpB | Tmath_0009 | Tmath_0975 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | 0.423 |
| gyrB | spoVG | Tmath_0009 | Tmath_2147 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | SpoVG family protein; Could be involved in septation. | 0.435 |
| murC | ADH61820.1 | Tmath_2149 | Tmath_2148 | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | KEGG: tpd:Teth39_0159 pur operon repressor; TIGRFAM: pur operon repressor; PFAM: purine repressor; phosphoribosyltransferase. | 0.693 |
| murC | glmU | Tmath_2149 | Tmath_2146 | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.847 |
