STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa)    
Predicted Functional Partners:
KUN64627.1
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.998
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.997
KUN70908.1
Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.991
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
 
 0.978
thiL
Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.966
KUN64893.1
Thiamine biosynthesis protein ThiC; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.952
rsgA
GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.903
rsgA-2
GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.891
KUN70909.1
Glycine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.889
mqnC
Dehypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
  
  
 0.854
Your Current Organism:
Streptomyces canus
NCBI taxonomy Id: 58343
Other names: ATCC 12237, ATCC 19737, ATCC 23626 [[Streptomyces ciscaucasicus]], ATCC 23918 [[Streptomyces ciscaucasicus]], BCRC 13652, CBS 475.68, CBS 839.68 [[Streptomyces ciscaucasicus]], CCRC 13652, CCRC:13652, DSM 40017, DSM 40275 [[Streptomyces ciscaucasicus]], IFO 12752, IFO 12872 [[Streptomyces ciscaucasicus]], IMET 42945 [[Streptomyces ciscaucasicus]], INA 2022/55 [[Streptomyces ciscaucasicus]], ISP 5017, ISP 5275 [[Streptomyces ciscaucasicus]], JCM 4212, JCM 4384 [[Streptomyces ciscaucasicus]], JCM 4569, LMG 19329, LMG:19329, NBRC 12752, NBRC 12872 [[Streptomyces ciscaucasicus]], NCIMB 9627, NRRL B-16362 [[Streptomyces ciscaucasicus]], NRRL B-3980, NRRL-ISP 5017, NRRL-ISP 5275 [[Streptomyces ciscaucasicus]], S. canus, Streptomyces ciscaucasicus, Streptomyces ciscaucasius, UNIQEM 125, VKM Ac-998 [[Streptomyces ciscaucasicus]], actinobacterium Act5(2011)
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.