STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KUN53268.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)    
Predicted Functional Partners:
KUN64911.1
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
  
 0.943
KUN57190.1
ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.943
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
    
 
 0.919
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.799
der
Ribosome-associated GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
  
  
 0.795
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.586
KUN73255.1
2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.502
KUN72717.1
RNA polymerase subunit sigma-70; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.488
KUN70248.1
RNA polymerase subunit sigma; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.488
sigA
RNA polymerase subunit sigma; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
  
 0.488
Your Current Organism:
Streptomyces canus
NCBI taxonomy Id: 58343
Other names: ATCC 12237, ATCC 19737, ATCC 23626 [[Streptomyces ciscaucasicus]], ATCC 23918 [[Streptomyces ciscaucasicus]], BCRC 13652, CBS 475.68, CBS 839.68 [[Streptomyces ciscaucasicus]], CCRC 13652, CCRC:13652, DSM 40017, DSM 40275 [[Streptomyces ciscaucasicus]], IFO 12752, IFO 12872 [[Streptomyces ciscaucasicus]], IMET 42945 [[Streptomyces ciscaucasicus]], INA 2022/55 [[Streptomyces ciscaucasicus]], ISP 5017, ISP 5275 [[Streptomyces ciscaucasicus]], JCM 4212, JCM 4384 [[Streptomyces ciscaucasicus]], JCM 4569, LMG 19329, LMG:19329, NBRC 12752, NBRC 12872 [[Streptomyces ciscaucasicus]], NCIMB 9627, NRRL B-16362 [[Streptomyces ciscaucasicus]], NRRL B-3980, NRRL-ISP 5017, NRRL-ISP 5275 [[Streptomyces ciscaucasicus]], S. canus, Streptomyces ciscaucasicus, Streptomyces ciscaucasius, UNIQEM 125, VKM Ac-998 [[Streptomyces ciscaucasicus]], actinobacterium Act5(2011)
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