STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Apau_0313Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (463 aa)    
Predicted Functional Partners:
Apau_0312
Glycine dehydrogenase (decarboxylating) beta subunit; COGs: COG1003 Glycine cleavage system protein P (pyridoxal-binding) C-terminal domain; InterPro IPR015421:IPR015424; KEGG: kcr:Kcr_0602 glycine dehydrogenase subunit 2; SPTR: B1L4H6 Glycine dehydrogenase (Decarboxylating); PFAM: Aminotransferase class-V.
0.999
Apau_0310
ATP-NAD/AcoX kinase; COGs: COG3199 conserved hypothetical protein; InterPro IPR011386:IPR002504; KEGG: kcr:Kcr_0603 ATP-NAD/AcoX kinase; PFAM: ATP-NAD/AcoX kinase; SPTR: B1L4H7 ATP-NAD/AcoX kinase; PFAM: ATP-NAD kinase.
 
     0.928
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.923
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.923
purQ
Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
  
 
  0.879
Apau_0427
2-amino-3-ketobutyrate coenzyme A ligase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterProIPR015421:IPR001917:IPR015424:IPR010962:IPR 004839; KEGG: tai:Taci_1652 pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; PRIAM: Glycine C-acetyltransferase; SPTR: D1B775 Pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; pyridoxal phosphate-dependent acyltransferase, putative.
  
 
 0.872
Apau_1943
COGs: COG2008 Threonine aldolase; InterPro IPR015424:IPR015421:IPR015422:IPR001597; KEGG: tai:Taci_1535 threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase; SPTR: C1TS32 Threonine aldolase; PFAM: Beta-eliminating lyase.
    
 0.872
Apau_0314
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347:IPR016040:IPR002198; KEGG: bbe:BBR47_57630 short chain dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: C0Z9N6 Short chain dehydrogenase; PFAM: short chain dehydrogenase.
 
   
 0.857
Apau_1391
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: tai:Taci_0968 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: D1BA97 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; TIGRFAM: sarcosine oxidase, beta subunit family, heterotetrameric form.
   
 
 0.846
Apau_0219
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: drm:Dred_1730 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: A4J5A2 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase.
   
 
 0.843
Your Current Organism:
Aminomonas paucivorans
NCBI taxonomy Id: 584708
Other names: A. paucivorans DSM 12260, Aminomonas paucivorans DSM 12260, Aminomonas paucivorans str. DSM 12260, Aminomonas paucivorans strain DSM 12260
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.