STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Experiments
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[Homology]
Score
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)    
Predicted Functional Partners:
Apau_1270
COGs: COG0469 Pyruvate kinase; InterProIPR015813:IPR015795:IPR008279:IPR011037:IPR 015794:IPR015793:IPR001697; KEGG: tai:Taci_0833 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; SPTR: D1B9W3 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
 
 0.999
pgi
COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR001672:IPR018189; KEGG: tai:Taci_0794 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); PRIAM: Glucose-6-phosphate isomerase; SPTR: D1B9S4 Glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase; Belongs to the GPI family.
 
 0.978
Apau_1261
1-phosphofructokinase; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR011611:IPR017583; KEGG: tai:Taci_0824 1-phosphofructokinase; PFAM: PfkB domain protein; SPTR: D1B9V4 1-phosphofructokinase; TIGRFAM: 1-phosphofructokinase; PFAM: pfkB family carbohydrate kinase; TIGRFAM: hexose kinase, 1-phosphofructokinase family.
  
  
 0.914
Apau_2191
Ketose-bisphosphate aldolase class-II; COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR013785:IPR000771; KEGG: tai:Taci_0218 ketose-bisphosphate aldolase class-II; PFAM: ketose-bisphosphate aldolase class-II; SPTR: D1B854 Ketose-bisphosphate aldolase class-II; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases.
 
 
 0.911
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
  
 0.906
pfp
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
  
  
 
0.875
Apau_0902
KpsF/GutQ family protein; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR000644:IPR004800:IPR001347; KEGG: tai:Taci_1281 KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; PRIAM: Arabinose-5-phosphate isomerase; SMART: CBS domain containing protein; SPTR: D1B671 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain; SIS domain; TIGRFAM: KpsF/GutQ family protein; Belongs to the SIS family. GutQ/KpsF subfamily.
  
 
 0.873
Apau_1587
Transketolase domain protein; COGs: COG0021 Transketolase; InterProIPR005474:IPR005475:IPR005476:IPR015941:IPR 009014; KEGG: tai:Taci_1130 transketolase central region; PFAM: Transketolase domain protein; Transketolase central region; SPTR: D1B5S1 Transketolase central region; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
  
 
 0.870
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
    
 0.865
Apau_0252
COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR002915:IPR013785; KEGG: tai:Taci_0152 fructose-bisphosphate aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; PRIAM: Fructose-bisphosphate aldolase; SPTR: D1B7Y9 Fructose-bisphosphate aldolase; PFAM: DeoC/LacD family aldolase.
    
 0.863
Your Current Organism:
Aminomonas paucivorans
NCBI taxonomy Id: 584708
Other names: A. paucivorans DSM 12260, Aminomonas paucivorans DSM 12260, Aminomonas paucivorans str. DSM 12260, Aminomonas paucivorans strain DSM 12260
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