STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisC-2COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR015424:IPR001176:IPR015421:IPR005861:IPR 004839; KEGG: tai:Taci_0230 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: D1B866 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa)    
Predicted Functional Partners:
hisB
COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR020568:IPR020565:IPR000807; KEGG: tai:Taci_0226 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: C1TLB1 Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase.
 
 0.999
hisI
COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR002496:IPR008179; KEGG: tai:Taci_0222 phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: D1B858 Phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.998
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.991
Apau_1752
COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099:IPR016040; KEGG: tai:Taci_1638 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; SPTR: C1TR74 Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase.
  
 
 0.944
hisA
Histidine biosynthesis protein; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterProIPR011060:IPR017926:IPR013785:IPR000991:IPR 006062; KEGG: tai:Taci_0224 histidine biosynthesis protein; PFAM: histidine biosynthesis protein; glutamine amidotransferase class-I; SPTR: C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; PFAM: Glutamine amidotransferase class-I; Histidine biosynthesis protein; TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; phosphoribosy [...]
 
  
 0.940
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.937
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.930
Apau_1755
COGs: COG0077 Prephenate dehydratase; InterProIPR008242:IPR002701:IPR001086:IPR020822:IPR 002912; KEGG: tai:Taci_1644 prephenate dehydratase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase; SPTR: C1TR93 Prephenate dehydratase; PFAM: Prephenate dehydratase; Chorismate mutase type II; ACT domain.
  
 
 0.917
Apau_1165
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterProIPR004839:IPR015424:IPR001176:IPR015421:IPR 004838; KEGG: tai:Taci_0746 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: D1B9M6 Aminotransferase class I and II; PFAM: Aminotransferase class I and II.
 
 
 0.914
Apau_2179
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.895
Your Current Organism:
Aminomonas paucivorans
NCBI taxonomy Id: 584708
Other names: A. paucivorans DSM 12260, Aminomonas paucivorans DSM 12260, Aminomonas paucivorans str. DSM 12260, Aminomonas paucivorans strain DSM 12260
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