| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| edd | leuA | DR95_2156 | DR95_2885 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.801 |
| edd | pabC | DR95_2156 | DR95_1219 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | pabC_Proteo: aminodeoxychorismate lyase. | 0.659 |
| edd | thrA | DR95_2156 | DR95_1906 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Bifunctional aspartokinase/homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.640 |
| folP | pabB | DR95_3261 | DR95_436 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | pabB: aminodeoxychorismate synthase, component I. | 0.555 |
| folP | pabC | DR95_3261 | DR95_1219 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | pabC_Proteo: aminodeoxychorismate lyase. | 0.683 |
| folP | thrA | DR95_3261 | DR95_1906 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Bifunctional aspartokinase/homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.469 |
| folP | trpG_2 | DR95_3261 | DR95_2727 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | trpG_papA: glutamine amidotransferase of anthranilate synthase/aminodeoxychorismate synthase family protein. | 0.605 |
| holB | mltG | DR95_1216 | DR95_1218 | holB: DNA polymerase III, delta' subunit. | yceG-like family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.840 |
| holB | pabC | DR95_1216 | DR95_1219 | holB: DNA polymerase III, delta' subunit. | pabC_Proteo: aminodeoxychorismate lyase. | 0.774 |
| holB | tmk | DR95_1216 | DR95_1217 | holB: DNA polymerase III, delta' subunit. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.956 |
| ilvD | leuA | DR95_3372 | DR95_2885 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.988 |
| ilvD | pabC | DR95_3372 | DR95_1219 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | pabC_Proteo: aminodeoxychorismate lyase. | 0.659 |
| ilvD | thrA | DR95_3372 | DR95_1906 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Bifunctional aspartokinase/homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.640 |
| leuA | edd | DR95_2885 | DR95_2156 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.801 |
| leuA | ilvD | DR95_2885 | DR95_3372 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.988 |
| leuA | pabC | DR95_2885 | DR95_1219 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | pabC_Proteo: aminodeoxychorismate lyase. | 0.727 |
| leuA | thrA | DR95_2885 | DR95_1906 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | Bifunctional aspartokinase/homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.749 |
| mltG | holB | DR95_1218 | DR95_1216 | yceG-like family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | holB: DNA polymerase III, delta' subunit. | 0.840 |
| mltG | pabC | DR95_1218 | DR95_1219 | yceG-like family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | pabC_Proteo: aminodeoxychorismate lyase. | 0.810 |
| mltG | tmk | DR95_1218 | DR95_1217 | yceG-like family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.843 |