| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| can | focA | DR95_1753 | DR95_1405 | Carbonic anhydrase 2; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | formate_focA: formate transporter FocA. | 0.806 |
| cobA | cysG | DR95_3394 | DR95_641 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.990 |
| cobA | focA | DR95_3394 | DR95_1405 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | formate_focA: formate transporter FocA. | 0.529 |
| cobA | nirD | DR95_3394 | DR95_640 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H] small subunit. | 0.803 |
| cysG | cobA | DR95_641 | DR95_3394 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.990 |
| cysG | focA | DR95_641 | DR95_1405 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | formate_focA: formate transporter FocA. | 0.535 |
| cysG | nirD | DR95_641 | DR95_640 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Nitrite reductase [NAD(P)H] small subunit. | 0.945 |
| feoA | focA | DR95_2646 | DR95_1405 | Ferrous iron transport protein A. | formate_focA: formate transporter FocA. | 0.483 |
| flgE | focA | DR95_302 | DR95_1405 | Flagellar hook protein flgE. | formate_focA: formate transporter FocA. | 0.441 |
| flgE | pal | DR95_302 | DR95_1534 | Flagellar hook protein flgE. | Peptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | 0.809 |
| focA | can | DR95_1405 | DR95_1753 | formate_focA: formate transporter FocA. | Carbonic anhydrase 2; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. | 0.806 |
| focA | cobA | DR95_1405 | DR95_3394 | formate_focA: formate transporter FocA. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.529 |
| focA | cysG | DR95_1405 | DR95_641 | formate_focA: formate transporter FocA. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.535 |
| focA | feoA | DR95_1405 | DR95_2646 | formate_focA: formate transporter FocA. | Ferrous iron transport protein A. | 0.483 |
| focA | flgE | DR95_1405 | DR95_302 | formate_focA: formate transporter FocA. | Flagellar hook protein flgE. | 0.441 |
| focA | nirD | DR95_1405 | DR95_640 | formate_focA: formate transporter FocA. | Nitrite reductase [NAD(P)H] small subunit. | 0.540 |
| focA | pal | DR95_1405 | DR95_1534 | formate_focA: formate transporter FocA. | Peptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | 0.483 |
| focA | pflA | DR95_1405 | DR95_1407 | formate_focA: formate transporter FocA. | Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. | 0.442 |
| focA | pflB | DR95_1405 | DR95_1406 | formate_focA: formate transporter FocA. | Pyr_form_ly_1: formate acetyltransferase. | 0.688 |
| focA | yaaH | DR95_1405 | DR95_3166 | formate_focA: formate transporter FocA. | Inner membrane protein yaaH. | 0.408 |