macB protein (Proteus vulgaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

macB

Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)

Predicted Functional Partners:

macA

0.998

acrA

0.936

mdtA_2

0.925

DR95_3670

0.925

mdtA_1

0.925

tolC

0.837

DR95_1125

0.827

DR95_981

0.827

lolE

0.787

lolC

0.787

Your Current Organism:

Proteus vulgaris

NCBI taxonomy Id: 585
Other names: ATCC 29905, CCUG 35382, CCUG 39507, CDC PR1, CIP 104989, DSM 13387, LMG 16708, LMG:16708, NCTC 13145, P. vulgaris, strain PR 1

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DR95_1125	macB	DR95_1125	DR95_1424	Putative periplasmic protein.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.827
DR95_3670	macB	DR95_3670	DR95_1424	type_I_hlyD: type I secretion membrane fusion, HlyD family protein.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.925
DR95_981	macB	DR95_981	DR95_1424	Hypothetical protein.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.827
acrA	macB	DR95_1789	DR95_1424	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.936
acrA	tolC	DR95_1789	DR95_2423	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Outer membrane protein tolC.	0.979
lolC	lolE	DR95_1205	DR95_1203	Lipo-releasing system transmembrane protein lolC.	lolE_release: liporeleasing system, transmembrane protein LolE.	0.975
lolC	macB	DR95_1205	DR95_1424	Lipo-releasing system transmembrane protein lolC.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.787
lolE	lolC	DR95_1203	DR95_1205	lolE_release: liporeleasing system, transmembrane protein LolE.	Lipo-releasing system transmembrane protein lolC.	0.975
lolE	macB	DR95_1203	DR95_1424	lolE_release: liporeleasing system, transmembrane protein LolE.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.787
macA	macB	DR95_1425	DR95_1424	Macrolide-specific efflux protein macA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.998
macA	mdtA_1	DR95_1425	DR95_456	Macrolide-specific efflux protein macA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.585
macA	mdtA_2	DR95_1425	DR95_2212	Macrolide-specific efflux protein macA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.618
macA	tolC	DR95_1425	DR95_2423	Macrolide-specific efflux protein macA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Outer membrane protein tolC.	0.876
macB	DR95_1125	DR95_1424	DR95_1125	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Putative periplasmic protein.	0.827
macB	DR95_3670	DR95_1424	DR95_3670	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	type_I_hlyD: type I secretion membrane fusion, HlyD family protein.	0.925
macB	DR95_981	DR95_1424	DR95_981	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Hypothetical protein.	0.827
macB	acrA	DR95_1424	DR95_1789	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.936
macB	lolC	DR95_1424	DR95_1205	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Lipo-releasing system transmembrane protein lolC.	0.787
macB	lolE	DR95_1424	DR95_1203	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	lolE_release: liporeleasing system, transmembrane protein LolE.	0.787
macB	macA	DR95_1424	DR95_1425	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Macrolide-specific efflux protein macA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.998

page 1 of 2

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About