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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acrBAcriflavine resistance protein B. (1049 aa)    
Predicted Functional Partners:
acrA
Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 0.999
mdtA_1
RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.850
tolC
Outer membrane protein tolC.
  
 
 0.774
macA
Macrolide-specific efflux protein macA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.740
yajC
Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
    
 
 0.723
acrZ
Hypothetical protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
    
   0.705
mdtA_2
RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.679
fadJ
Fatty oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
     
 0.553
acrR
HTH-type transcriptional regulator AcrR.
     
 0.542
macB
Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 
 0.488
Your Current Organism:
Proteus vulgaris
NCBI taxonomy Id: 585
Other names: ATCC 29905, CCUG 35382, CCUG 39507, CDC PR1, CIP 104989, DSM 13387, LMG 16708, LMG:16708, NCTC 13145, P. vulgaris, strain PR 1
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