Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
degSprotease_degS: periplasmic serine peptidase DegS. (356 aa)    
Predicted Functional Partners:
rseA
sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...]
  
 
 0.963
arcB
Aerobic respiration control sensor protein ArcB.
  
  
 0.711
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
   
 0.580
rseP
RIP metalloprotease RseP.
 
  
 0.579
degQ
degP_htrA_DO: peptidase Do family protein; Belongs to the peptidase S1C family.
 
    
0.534
pspC
phageshock_pspC: phage shock protein C.
  
  
 0.513
cpxA
Sensor protein CpxA.
  
 0.508
rpsP
S16: ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.
 
   0.481
yhcB
Putative cytochrome d ubiquinol oxidase subunit 3.
 
   
 0.467
DR95_2826
Ankyrin repeat family protein.
  
 0.463
Your Current Organism:
Proteus vulgaris
NCBI taxonomy Id: 585
Other names: ATCC 29905, CCUG 35382, CCUG 39507, CDC PR1, CIP 104989, DSM 13387, LMG 16708, LMG:16708, NCTC 13145, P. vulgaris, strain PR 1
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