| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DR95_786 | frdB | DR95_786 | DR95_2059 | 4Fe-4S binding domain protein. | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.603 |
| DR95_786 | nfuA | DR95_786 | DR95_2640 | 4Fe-4S binding domain protein. | fe/S biogenesis protein nfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.790 |
| DR95_786 | sdhB | DR95_786 | DR95_1551 | 4Fe-4S binding domain protein. | Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.603 |
| bssD | frdB | DR95_2205 | DR95_2059 | PFLE_PFLC: glycyl-radical enzyme activating family protein. | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.589 |
| bssD | iscS | DR95_2205 | DR95_88 | PFLE_PFLC: glycyl-radical enzyme activating family protein. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.451 |
| bssD | nfuA | DR95_2205 | DR95_2640 | PFLE_PFLC: glycyl-radical enzyme activating family protein. | fe/S biogenesis protein nfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.760 |
| bssD | nifU | DR95_2205 | DR95_89 | PFLE_PFLC: glycyl-radical enzyme activating family protein. | nifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.525 |
| bssD | sdhB | DR95_2205 | DR95_1551 | PFLE_PFLC: glycyl-radical enzyme activating family protein. | Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.589 |
| djlA | grxD | DR95_2441 | DR95_1012 | dnaJ-like protein djlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Monothiol glutaredoxin, Grx4 family; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.411 |
| djlA | iscS | DR95_2441 | DR95_88 | dnaJ-like protein djlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.665 |
| djlA | nfuA | DR95_2441 | DR95_2640 | dnaJ-like protein djlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | fe/S biogenesis protein nfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.842 |
| djlA | nifU | DR95_2441 | DR95_89 | dnaJ-like protein djlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | nifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.939 |
| frdB | DR95_786 | DR95_2059 | DR95_786 | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 4Fe-4S binding domain protein. | 0.603 |
| frdB | bssD | DR95_2059 | DR95_2205 | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | PFLE_PFLC: glycyl-radical enzyme activating family protein. | 0.589 |
| frdB | nfuA | DR95_2059 | DR95_2640 | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | fe/S biogenesis protein nfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.865 |
| frdB | nuoI | DR95_2059 | DR95_202 | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | NADH-quinone oxidoreductase, chain I family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. | 0.589 |
| frdB | sdhB | DR95_2059 | DR95_1551 | Fumarate reductase iron-sulfur subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.913 |
| grxD | djlA | DR95_1012 | DR95_2441 | Monothiol glutaredoxin, Grx4 family; Belongs to the glutaredoxin family. Monothiol subfamily. | dnaJ-like protein djlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | 0.411 |
| grxD | hscB | DR95_1012 | DR95_91 | Monothiol glutaredoxin, Grx4 family; Belongs to the glutaredoxin family. Monothiol subfamily. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.411 |
| grxD | nfuA | DR95_1012 | DR95_2640 | Monothiol glutaredoxin, Grx4 family; Belongs to the glutaredoxin family. Monothiol subfamily. | fe/S biogenesis protein nfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.791 |
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