def-2 protein (Proteus vulgaris) - STRING interaction network

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def-2

Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (172 aa)

Predicted Functional Partners:

rplV

0.889

rplQ

0.881

rpsJ

0.879

rpsP

0.879

rplI

0.878

rplU

0.870

rplT

0.869

rpmA

0.867

tig

0.852

rpsT

0.846

Your Current Organism:

Proteus vulgaris

NCBI taxonomy Id: 585
Other names: ATCC 29905, CCUG 35382, CCUG 39507, CDC PR1, CIP 104989, DSM 13387, LMG 16708, LMG:16708, NCTC 13145, P. vulgaris, strain PR 1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
def-2	rplI	DR95_2724	DR95_3300	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L9; Binds to the 23S rRNA.	0.878
def-2	rplQ	DR95_2724	DR95_2117	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	L17: ribosomal protein L17.	0.881
def-2	rplT	DR95_2724	DR95_1069	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.869
def-2	rplU	DR95_2724	DR95_3269	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.870
def-2	rplV	DR95_2724	DR95_2138	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.889
def-2	rpmA	DR95_2724	DR95_3268	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	L27: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.867
def-2	rpsJ	DR95_2724	DR95_2144	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.879
def-2	rpsP	DR95_2724	DR95_3604	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	S16: ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.	0.879
def-2	rpsT	DR95_2724	DR95_1892	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein S20; Binds directly to 16S ribosomal RNA.	0.846
def-2	tig	DR95_2724	DR95_1807	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.	0.852
rplI	def-2	DR95_3300	DR95_2724	Ribosomal protein L9; Binds to the 23S rRNA.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.878
rplI	rplQ	DR95_3300	DR95_2117	Ribosomal protein L9; Binds to the 23S rRNA.	L17: ribosomal protein L17.	0.996
rplI	rplT	DR95_3300	DR95_1069	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.996
rplI	rplU	DR95_3300	DR95_3269	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.996
rplI	rplV	DR95_3300	DR95_2138	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.997
rplI	rpmA	DR95_3300	DR95_3268	Ribosomal protein L9; Binds to the 23S rRNA.	L27: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.993
rplI	rpsJ	DR95_3300	DR95_2144	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.991
rplI	rpsP	DR95_3300	DR95_3604	Ribosomal protein L9; Binds to the 23S rRNA.	S16: ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.	0.995
rplI	rpsT	DR95_3300	DR95_1892	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein S20; Binds directly to 16S ribosomal RNA.	0.975
rplI	tig	DR95_3300	DR95_1807	Ribosomal protein L9; Binds to the 23S rRNA.	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.	0.974

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