node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ada | mutM | DR95_849 | DR95_3101 | Ogt: methylated-DNA-[]-cysteine S-methyltransferase family protein. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.408 |
ada | mutY | DR95_849 | DR95_3666 | Ogt: methylated-DNA-[]-cysteine S-methyltransferase family protein. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.509 |
ada | xth | DR95_849 | DR95_622 | Ogt: methylated-DNA-[]-cysteine S-methyltransferase family protein. | exoDNase_III: exodeoxyribonuclease III. | 0.523 |
birA | mutY | DR95_3679 | DR95_3666 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.578 |
birA | trmB | DR95_3679 | DR95_3665 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.514 |
birA | trpC | DR95_3679 | DR95_956 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Indole-3-glycerol phosphate synthase family protein; Belongs to the TrpC family. | 0.471 |
birA | xth | DR95_3679 | DR95_622 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | exoDNase_III: exodeoxyribonuclease III. | 0.861 |
mltC | mutY | DR95_3668 | DR95_3666 | Hypothetical protein; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.582 |
mltC | trmB | DR95_3668 | DR95_3665 | Hypothetical protein; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.452 |
mltC | yggX | DR95_3668 | DR95_3667 | Hypothetical protein; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | Putative Fe(2+)-trafficking protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.672 |
mutM | ada | DR95_3101 | DR95_849 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Ogt: methylated-DNA-[]-cysteine S-methyltransferase family protein. | 0.408 |
mutM | mutY | DR95_3101 | DR95_3666 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.527 |
mutY | ada | DR95_3666 | DR95_849 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Ogt: methylated-DNA-[]-cysteine S-methyltransferase family protein. | 0.509 |
mutY | birA | DR95_3666 | DR95_3679 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.578 |
mutY | mltC | DR95_3666 | DR95_3668 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Hypothetical protein; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | 0.582 |
mutY | mutM | DR95_3666 | DR95_3101 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.527 |
mutY | ppa | DR95_3666 | DR95_3278 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.696 |
mutY | sfsA | DR95_3666 | DR95_1715 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | sfsA: sugar fermentation stimulation protein; Belongs to the SfsA family. | 0.926 |
mutY | trmB | DR95_3666 | DR95_3665 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.564 |
mutY | trpC | DR95_3666 | DR95_956 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Indole-3-glycerol phosphate synthase family protein; Belongs to the TrpC family. | 0.746 |