STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseAsigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] (208 aa)    
Predicted Functional Partners:
rseB
sigma-E factor regulatory protein rseB.
 
 
 0.998
rpoE
rpoE_Sigma70: RNA polymerase sigma factor RpoE; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.990
fecI
sigma70-ECF: RNA polymerase sigma factor, sigma-70 family protein.
  
 
 0.904
DR95_2016
Hypothetical protein.
 
 
 0.875
degS
protease_degS: periplasmic serine peptidase DegS.
  
 
 0.856
degQ
degP_htrA_DO: peptidase Do family protein; Belongs to the peptidase S1C family.
  
 
 0.806
rseC
sigma-E factor regulatory protein rseC.
 
  
 0.785
sspB
Stringent starvation protein B.
    
 
 0.772
DR95_395
SEC-C motif family protein.
  
 
 0.771
lptC
Lipopolysaccharide export system protein lptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.713
Your Current Organism:
Proteus vulgaris
NCBI taxonomy Id: 585
Other names: ATCC 29905, CCUG 35382, CCUG 39507, CDC PR1, CIP 104989, DSM 13387, LMG 16708, LMG:16708, NCTC 13145, P. vulgaris, strain PR 1
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