| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DR95_616 | ansA | DR95_616 | DR95_617 | Isochorismatase family protein. | L-asparaginase 1. | 0.842 |
| DR95_616 | birA | DR95_616 | DR95_3679 | Isochorismatase family protein. | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.459 |
| DR95_616 | cobB | DR95_616 | DR95_1202 | Isochorismatase family protein. | NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. | 0.915 |
| DR95_616 | deoD | DR95_616 | DR95_2348 | Isochorismatase family protein. | deoD: purine nucleoside phosphorylase. | 0.901 |
| DR95_616 | guaA | DR95_616 | DR95_499 | Isochorismatase family protein. | GMP synthase glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.437 |
| DR95_616 | nadC | DR95_616 | DR95_2241 | Isochorismatase family protein. | Hypothetical protein; Quinolinate phosphoribosyl transferase, N-terminal domain protein; Belongs to the NadC/ModD family. | 0.436 |
| DR95_616 | nadD | DR95_616 | DR95_1608 | Isochorismatase family protein. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.431 |
| DR95_616 | nadE | DR95_616 | DR95_79 | Isochorismatase family protein. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.573 |
| DR95_616 | pncB | DR95_616 | DR95_1377 | Isochorismatase family protein. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.982 |
| DR95_616 | trmJ | DR95_616 | DR95_86 | Isochorismatase family protein. | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.527 |
| ansA | DR95_616 | DR95_617 | DR95_616 | L-asparaginase 1. | Isochorismatase family protein. | 0.842 |
| birA | DR95_616 | DR95_3679 | DR95_616 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Isochorismatase family protein. | 0.459 |
| birA | guaA | DR95_3679 | DR95_499 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GMP synthase glutamine-hydrolyzing; Catalyzes the synthesis of GMP from XMP. | 0.650 |
| birA | nadD | DR95_3679 | DR95_1608 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.551 |
| birA | nadE | DR95_3679 | DR95_79 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.666 |
| birA | pncB | DR95_3679 | DR95_1377 | Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.539 |
| cobB | DR95_616 | DR95_1202 | DR95_616 | NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. | Isochorismatase family protein. | 0.915 |
| cobB | deoD | DR95_1202 | DR95_2348 | NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. | deoD: purine nucleoside phosphorylase. | 0.922 |
| cobB | nadD | DR95_1202 | DR95_1608 | NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.930 |
| cobB | nadE | DR95_1202 | DR95_79 | NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.948 |