STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybhTConserved hypothetical protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (49 aa)    
Predicted Functional Partners:
acrA
Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
    
 
 0.958
acrB
Multidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter.
    
 
 0.934
tolC
Transport channel; Function experimentally demonstrated in the studied species; transporter.
    
 
 0.923
modE
DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator.
       0.609
mdtF
Multidrug transporter, RpoS-dependent; Function experimentally demonstrated in the studied species; transporter.
    
 
 0.525
modA
Molybdate transporter subunit; Function experimentally demonstrated in the studied species; transporter.
       0.522
acrF
Multidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter.
    
 
 0.516
modB
Molybdate transporter subunit; Function experimentally demonstrated in the studied species; transporter.
       0.470
modC
Molybdate transporter subunit; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
       0.470
emrD
Multidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter.
      
 0.459
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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