STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sulASOS cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (169 aa)    
Predicted Functional Partners:
recN
Recombination and repair protein; May be involved in recombinational repair of damaged DNA.
   
  
 0.927
ftsZ
GTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
    
 
 0.886
yebG
Conserved hypothetical protein regulated by LexA; Homologs of previously reported genes of unknown function; cell process.
   
    0.802
hslU
Molecular chaperone and ATPase component of HslUV protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
    
   0.750
yfaZ
Putative outer membrane porin protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
  
     0.749
yhhN
Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component.
  
     0.745
bcsE
Putative protease involved in cellulose biosynthesis; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
     0.728
yjeP
Putative mechanosensitive channel; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.
  
  
 0.722
flgN
Export chaperone for FlgK and FlgL; Function experimentally demonstrated in the studied species; factor.
  
     0.716
yggN
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
     0.710
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.