node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ampD | ampG | ECIAI1_0107 | ECIAI1_0436 | N-acetyl-anhydromuranmyl-L-alanine amidase; Function experimentally demonstrated in the studied species; enzyme. | Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. | 0.922 |
ampD | anmK | ECIAI1_0107 | ECIAI1_1692 | N-acetyl-anhydromuranmyl-L-alanine amidase; Function experimentally demonstrated in the studied species; enzyme. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.688 |
ampD | nagZ | ECIAI1_0107 | ECIAI1_1144 | N-acetyl-anhydromuranmyl-L-alanine amidase; Function experimentally demonstrated in the studied species; enzyme. | Beta N-acetyl-glucosaminidase; Function experimentally demonstrated in the studied species; enzyme. | 0.932 |
ampG | ampD | ECIAI1_0436 | ECIAI1_0107 | Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. | N-acetyl-anhydromuranmyl-L-alanine amidase; Function experimentally demonstrated in the studied species; enzyme. | 0.922 |
ampG | anmK | ECIAI1_0436 | ECIAI1_1692 | Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.689 |
ampG | nagZ | ECIAI1_0436 | ECIAI1_1144 | Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. | Beta N-acetyl-glucosaminidase; Function experimentally demonstrated in the studied species; enzyme. | 0.875 |
ampG | yfeU | ECIAI1_0436 | ECIAI1_2485 | Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. | Putative PTS component; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. | 0.655 |
anmK | ampD | ECIAI1_1692 | ECIAI1_0107 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetyl-anhydromuranmyl-L-alanine amidase; Function experimentally demonstrated in the studied species; enzyme. | 0.688 |
anmK | ampG | ECIAI1_1692 | ECIAI1_0436 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. | 0.689 |
anmK | gcvP | ECIAI1_1692 | ECIAI1_3022 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.428 |
anmK | nagZ | ECIAI1_1692 | ECIAI1_1144 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Beta N-acetyl-glucosaminidase; Function experimentally demonstrated in the studied species; enzyme. | 0.905 |
anmK | pdxH | ECIAI1_1692 | ECIAI1_1690 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.435 |
anmK | ribD | ECIAI1_1692 | ECIAI1_0414 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; Function experimentally demonstrated in the studied species; enzyme. | 0.421 |
anmK | slyB | ECIAI1_1692 | ECIAI1_1693 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Putative outer membrane lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; lipoprotein. | 0.431 |
anmK | ydhA | ECIAI1_1692 | ECIAI1_1691 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Putative lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; lipoprotein. | 0.578 |
anmK | yfeU | ECIAI1_1692 | ECIAI1_2485 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Putative PTS component; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. | 0.993 |
gcvP | anmK | ECIAI1_3022 | ECIAI1_1692 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.428 |
gcvP | pdxH | ECIAI1_3022 | ECIAI1_1690 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.527 |
nagZ | ampD | ECIAI1_1144 | ECIAI1_0107 | Beta N-acetyl-glucosaminidase; Function experimentally demonstrated in the studied species; enzyme. | N-acetyl-anhydromuranmyl-L-alanine amidase; Function experimentally demonstrated in the studied species; enzyme. | 0.932 |
nagZ | ampG | ECIAI1_1144 | ECIAI1_0436 | Beta N-acetyl-glucosaminidase; Function experimentally demonstrated in the studied species; enzyme. | Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. | 0.875 |