STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nikRDNA-binding transcriptional repressor, Ni-binding; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. (133 aa)    
Predicted Functional Partners:
nikA
Nickel transporter subunit; Function experimentally demonstrated in the studied species; transporter.
     
 0.923
nikD
Nickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
     
 0.870
nikC
Nickel transporter subunit; Function experimentally demonstrated in the studied species; transporter.
  
  
 0.855
nikE
Nickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
   
 0.851
nikB
Nickel transporter subunit; Function experimentally demonstrated in the studied species; transporter.
     
 0.836
rncA
Nickel and cobalt resistance; Efflux system for nickel and cobalt.
  
   
 0.835
yohL
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
      
 0.822
arsR
DNA-binding transcriptional repressor; Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
      
 0.807
chpA
Toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease; Function experimentally demonstrated in the studied species; enzyme.
  
 
 0.678
chpB
Toxin of the ChpB-ChpS toxin-antitoxin system; Function experimentally demonstrated in the studied species; factor.
  
 
 0.678
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.