STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dsbAPeriplasmic protein disulfide isomerase I; Function experimentally demonstrated in the studied species; enzyme. (208 aa)    
Predicted Functional Partners:
dsbB
Oxidoreductase that catalyzes reoxidation of DsbA protein disulfide isomerase I; Function experimentally demonstrated in the studied species; enzyme.
 
 
 0.999
dsbC
Protein disulfide isomerase II; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
  
  
 0.954
dipZ
Fused thiol:disulfide interchange protein: activator of DsbC; Function experimentally demonstrated in the studied species; enzyme.
  
 
 0.947
ccmG
Periplasmic thioredoxin of cytochrome c-type biogenesis; Function experimentally demonstrated in the studied species; enzyme.
  
 
 0.871
surA
Peptidyl-prolyl cis-trans isomerase (PPIase); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
  
 
 0.853
yihE
Putative kinase; Function of strongly homologous gene; putative enzyme.
 
  
 0.832
dsbG
Periplasmic disulfide isomerase/thiol-disulphide oxidase; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
      
 0.821
degP
Serine endoprotease (protease Do), membrane-associated; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S1C family.
   
  
 0.813
yicH
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 
     0.758
yiiU
Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
  
    0.752
Your Current Organism:
Escherichia coli IAI1
NCBI taxonomy Id: 585034
Other names: E. coli IAI1, Escherichia coli str. IAI1, Escherichia coli strain IAI1
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