node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dnaB | dnaE | ECUMN_4586 | ECUMN_0181 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.948 |
dnaB | dnaN | ECUMN_4586 | ECUMN_4232 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.891 |
dnaB | dnaQ | ECUMN_4586 | ECUMN_0212 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.475 |
dnaB | dnaX | ECUMN_4586 | ECUMN_0509 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.954 |
dnaB | holA | ECUMN_4586 | ECUMN_0734 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, delta subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.445 |
dnaB | holB | ECUMN_4586 | ECUMN_1276 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, delta prime subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.573 |
dnaB | ssb | ECUMN_4586 | ECUMN_4595 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | 0.904 |
dnaE | dnaB | ECUMN_0181 | ECUMN_4586 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.948 |
dnaE | dnaN | ECUMN_0181 | ECUMN_4232 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.999 |
dnaE | dnaQ | ECUMN_0181 | ECUMN_0212 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.999 |
dnaE | dnaX | ECUMN_0181 | ECUMN_0509 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.999 |
dnaE | holA | ECUMN_0181 | ECUMN_0734 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III, delta subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.999 |
dnaE | holB | ECUMN_0181 | ECUMN_1276 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III, delta prime subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.999 |
dnaE | holC | ECUMN_0181 | ECUMN_4791 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III, chi subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.999 |
dnaE | holD | ECUMN_0181 | ECUMN_4995 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.999 |
dnaE | holE | ECUMN_0181 | ECUMN_2137 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | DNA polymerase III, theta subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.999 |
dnaE | ssb | ECUMN_0181 | ECUMN_4595 | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | 0.999 |
dnaN | dnaB | ECUMN_4232 | ECUMN_4586 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.891 |
dnaN | dnaE | ECUMN_4232 | ECUMN_0181 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III alpha subunit; Function experimentally demonstrated in the studied species; enzyme. | 0.999 |
dnaN | dnaQ | ECUMN_4232 | ECUMN_0212 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.998 |