STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ycfJConserved hypothetical protein; Homologs of previously reported genes of unknown function; 7984428. (179 aa)    
Predicted Functional Partners:
ypfG
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
   
  
 0.861
rseA
Anti-sigma factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading [...]
   
    0.751
yeeA
Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component.
  
     0.534
yeeI
Conserved hypothetical protein; Involved in the regulation of ptsG expression by binding and inactivating Mlc.
  
     0.483
osmB
Lipoprotein; Function experimentally demonstrated in the studied species; lipoprotein.
   
  
 0.480
yhjG
Putative outer membrane biogenesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component.
  
     0.480
rstB
Sensory histidine kinase in two-component regulatory system with RstA; Function experimentally demonstrated in the studied species; regulator.
  
     0.451
ndh
Respiratory NADH dehydrogenase 2/cupric reductase; Function experimentally demonstrated in the studied species; enzyme.
       0.431
yaiW
Putative lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component.
  
     0.420
ygaC
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
  
 0.417
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.