STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygaTConserved hypothetical protein; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (325 aa)    
Predicted Functional Partners:
ygaF
Putative enzyme; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family.
 
 
 0.999
gabD
Succinate-semialdehyde dehydrogenase I, NADP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aldehyde dehydrogenase family.
  
 
 0.993
gabT
4-aminobutyrate aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.927
csiR
DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator.
 
   
 0.833
yjcO
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
     0.587
CAR12089.1
Hypothetical protein from phage origin, putative nucleoid-associated protein; No homology to any previously reported sequences; extrachromosomal origin.
  
     0.551
yneI
Putative aldehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 
  0.519
mqo
Malate dehydrogenase, FAD/NAD(P)-binding domain; Function experimentally demonstrated in the studied species; enzyme.
  
  
 0.501
gabP
Gamma-aminobutyrate transporter; Function experimentally demonstrated in the studied species; transporter.
  
  
 0.498
CAR12514.1
Exodeoxyribonuclease VIII from bacteriophage origin; Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin.
  
     0.485
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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