STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
emrBMultidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter; Belongs to the major facilitator superfamily. (512 aa)    
Predicted Functional Partners:
emrA
Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter.
 
 0.999
tolC
Transport channel; Function experimentally demonstrated in the studied species; transporter.
  
 
 0.975
emrK
EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component; Function experimentally demonstrated in the studied species; transporter.
 
 
 0.900
mprA
DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; Function experimentally demonstrated in the studied species; regulator.
 
   
 0.894
cmr
Multidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter.
  
   
 0.689
mdtB
Multidrug efflux system, subunit B; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
  
 
 0.688
emrD
Multidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter.
  
   
 0.686
macB
Fused macrolide transporter subunits of ABC superfamily: ATP-binding component; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
   
 
 0.646
mdtK
Multidrug efflux system transporter; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
      
 0.630
acrA
Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.629
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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