STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cusACopper/silver efflux system, membrane component; Function experimentally demonstrated in the studied species; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1047 aa)    
Predicted Functional Partners:
cusC
Copper/silver efflux system, outer membrane component; Function experimentally demonstrated in the studied species; transporter.
 
 0.999
cusB
Copper/silver efflux system, membrane fusion protein; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 0.999
cusF
Periplasmic copper-binding protein; Function of strongly homologous gene; factor.
 
 
 0.993
cusS
Fragment of bacteriophage N4 receptor, inner membrane subunit (part 1); Member of a two-component regulatory system.
 
   
 0.926
cusR
DNA-binding response regulator in two-component regulatory system with CusS; Function experimentally demonstrated in the studied species; regulator.
 
  
 0.921
cueO
Multicopper oxidase (laccase); Function experimentally demonstrated in the studied species; enzyme.
     
 0.827
acrA
Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.757
macA
Macrolide transporter subunit, membrane fusion protein (MFP) component; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.652
cueR
DNA-binding transcriptional activator of copper-responsive regulon genes; Function experimentally demonstrated in the studied species; regulator.
     
 0.644
mdtA
Multidrug efflux system, subunit A; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.534
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.