STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseAAnti-sigma factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading [...] (216 aa)    
Predicted Functional Partners:
rseB
Anti-sigma factor; Function experimentally demonstrated in the studied species; factor.
 
 
 0.999
rpoE
RNA polymerase, sigma 24 (sigma E) factor; Function experimentally demonstrated in the studied species; factor; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.999
degS
Serine endoprotease, periplasmic; Function experimentally demonstrated in the studied species; enzyme.
  
 
 0.977
rseC
RseC protein involved in reduction of the SoxR iron-sulfur cluster; Function experimentally demonstrated in the studied species; cell process.
 
  
 0.963
yaeL
Zinc metallopeptidase; Function experimentally demonstrated in the studied species; enzyme.
  
 
 
 0.878
degP
Serine endoprotease (protease Do), membrane-associated; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S1C family.
 
 
 0.873
sspB
ClpXP protease specificity-enhancing factor; Function experimentally demonstrated in the studied species; factor.
  
 
 
 0.867
flgM
Anti-sigma factor for FliA (sigma 28); Function experimentally demonstrated in the studied species; factor.
  
   
 0.862
fecI
RNA polymerase, sigma 19 factor; Function experimentally demonstrated in the studied species; regulator; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.827
rpoD
RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
  
 0.772
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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